A Unique Plasmodium falciparum K13 Gene Mutation in Northwest Ethiopia

被引：51

作者：

Bayih, Abebe Genetu

Getnet, Gebeyaw

Alemu, Abebe

Getie, Sisay

Mohon, Abu Naser

Pillai, Dylan R. ^{[1
]}

机构：

[1] Univ Calgary, Dept Pathol & Lab Med, Calgary, AB T2L 2K8, Canada

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2016年 / 94卷 / 01期

关键词：

ARTEMISININ RESISTANCE MUTATIONS; SPREAD;

D O I：

10.4269/ajtmh.15-0477

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Artemisinin combination therapy (ACT) is the first line to treat uncomplicated Plasmodium falciparum malaria worldwide. Artemisinin treatment failures are on the rise in southeast Asia. Delayed parasite clearance after ACT is associated with mutations of the P. falciparum kelch 13 gene. Patients (N = 148) in five districts of northwest Ethiopia were enrolled in a 28-day ACT trial. We identified a unique kelch 13 mutation (R622I) in 3/125 (2.4%) samples. The three isolates with R622I were from Negade-Bahir and Aykel districts close to the Ethiopia Sudan border. One of three patients with the mutant strain was parasitemic at day 3; however, all patients cleared parasites by day 28. Correlation between kelch 13 mutations and parasite clearance was not possible due to the low frequency of mutations in this study.

引用

页码：132 / 135

页数：4

共 20 条

[1]

[Anonymous], 2014, World Malaria Report

[2] A molecular marker of artemisinin-resistant Plasmodium falciparum malaria [J].

Ariey, Frederic ;

Witkowski, Benoit ;

Amaratunga, Chanaki ;

Beghain, Johann ;

Langlois, Anne-Claire ;

Khim, Nimol ;

Kim, Saorin ;

Duru, Valentine ;

Bouchier, Christiane ;

Ma, Laurence ;

Lim, Pharath ;

Leang, Rithea ;

Duong, Socheat ;

Sreng, Sokunthea ;

Suon, Seila ;

Chuor, Char Meng ;

Bout, Denis Mey ;

Menard, Sandie ;

Rogers, William O. ;

Genton, Blaise ;

Fandeur, Thierry ;

Miotto, Olivo ;

Ringwald, Pascal ;

Le Bras, Jacques ;

Berry, Antoine ;

Barale, Jean-Christophe ;

Fairhurst, Rick M. ;

Benoit-Vical, Franoise ;

Mercereau-Puijalon, Odile ;

Menard, Didier .

NATURE, 2014, 505 (7481) :50-+

[3] Spread of Artemisinin Resistance in Plasmodium falciparum Malaria [J].

Ashley, E. A. ;

Dhorda, M. ;

Fairhurst, R. M. ;

Amaratunga, C. ;

Lim, P. ;

Suon, S. ;

Sreng, S. ;

Anderson, J. M. ;

Mao, S. ;

Sam, B. ;

Sopha, C. ;

Chuor, C. M. ;

Nguon, C. ;

Sovannaroth, S. ;

Pukrittayakamee, S. ;

Jittamala, P. ;

Chotivanich, K. ;

Chutasmit, K. ;

Suchatsoonthorn, C. ;

Runcharoen, R. ;

Hien, T. T. ;

Thuy-Nhien, N. T. ;

Thanh, N. V. ;

Phu, N. H. ;

Htut, Y. ;

Han, K-T. ;

Aye, K. H. ;

Mokuolu, O. A. ;

Olaosebikan, R. R. ;

Folaranmi, O. O. ;

Mayxay, M. ;

Khanthavong, M. ;

Hongvanthong, B. ;

Newton, P. N. ;

Onyamboko, M. A. ;

Fanello, C. I. ;

Tshefu, A. K. ;

Mishra, N. ;

Valecha, N. ;

Phyo, A. P. ;

Nosten, F. ;

Yi, P. ;

Tripura, R. ;

Borrmann, S. ;

Bashraheil, M. ;

Peshu, J. ;

Faiz, M. A. ;

Ghose, A. ;

Hossain, M. A. ;

Samad, R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (05) :411-423

[4] The Jalview Java']Java alignment editor [J].

Clamp, M ;

Cuff, J ;

Searle, SM ;

Barton, GJ .

BIOINFORMATICS, 2004, 20 (03) :426-427

[5] Artemisinin Resistance in Plasmodium falciparum Malaria. [J].

Dondorp, Arjen M. ;

Nosten, Francois ;

Yi, Poravuth ;

Das, Debashish ;

Phyo, Aung Phae ;

Tarning, Joel ;

Lwin, Khin Maung ;

Ariey, Frederic ;

Hanpithakpong, Warunee ;

Lee, Sue J. ;

Ringwald, Pascal ;

Silamut, Kamolrat ;

Imwong, Mallika ;

Chotivanich, Kesinee ;

Lim, Pharath ;

Herdman, Trent ;

An, Sen Sam ;

Yeung, Shunmay ;

Singhasivanon, Pratap ;

Day, Nicholas P. J. ;

Lindegardh, Niklas ;

Socheat, Duong ;

White, Nicholas J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (05) :455-467

[6] Polymorphisms in Plasmodium falciparum K13-Propeller in Angola and Mozambique after the Introduction of the ACTs [J].

Escobar, Carlos ;

Pateira, Sara ;

Lobo, Elsa ;

Lobo, Lis ;

Teodosio, Rosa ;

Dias, Fernanda ;

Fernandes, Natercia ;

Arez, Ana Paula ;

Varandas, Luis ;

Nogueira, Fatima .

PLOS ONE, 2015, 10 (03)

[7] K13-Propeller Polymorphisms in Plasmodium falciparum Parasites From Sub-Saharan Africa [J].

Kamau, Edwin ;

Campino, Susana ;

Amenga-Etego, Lucas ;

Drury, Eleanor ;

Ishengoma, Deus ;

Johnson, Kimberly ;

Mumba, Dieudonne ;

Kekre, Mihir ;

Yavo, William ;

Mead, Daniel ;

Bouyou-Akotet, Marielle ;

Apinjoh, Tobias ;

Golassa, Lemu ;

Randrianarivelojosia, Milijaona ;

Andagalu, Ben ;

Maiga-Ascofare, Oumou ;

Amambua-Ngwa, Alfred ;

Tindana, Paulina ;

Ghansah, Anita ;

MacInnis, Bronwyn ;

Kwiatkowski, Dominic ;

Djimde, Abdoulaye A. .

JOURNAL OF INFECTIOUS DISEASES, 2015, 211 (08) :1352-1355

[8] Protein structure prediction on the Web: a case study using the Phyre server [J].

Kelley, Lawrence A. ;

Sternberg, Michael J. E. .

NATURE PROTOCOLS, 2009, 4 (03) :363-371

[9]

Ministry of Health The Federal Democratic Republic of Ethiopia, 2010, MAL DIAGN TREATM GUI

[10]

Ministry of Health The Federal Democratic Republic of Ethiopia, 2010, NAT STRAT PLAN MAL P

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