Siglecs: sialic-acid-binding immunoglobulin-like lectins in cell-cell interactions and signalling

被引：263

作者：

Crocker, PR ^{[1
]}

机构：

[1] Univ Dundee, Wellcome Trust Bioctr Dundee, Div Cell Biol & Immunol, Sch Life Sci, Dundee DD1 5EH, Scotland

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2002年 / 12卷 / 05期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/S0959-440X(02)00375-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Siglecs are sialic-acid-binding immunoglobulin-like lectins involved in cell-cell interactions and signalling functions in the haemopoietic, immune and nervous systems, Significant advances have been made in our understanding of the link between carbohydrate recognition and signalling for two well-characterised siglecs, CD22 and myelin-associated glycoprotein. Over the past few years, several novel siglecs have been discovered through genomics and functional screens. These 'CD33-related' siglecs have molecular features of inhibitory receptors and may be important in regulating leucocyte activation during immune and inflammatory responses.

引用

页码：609 / 615

页数：7

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