Physical preparation of alginate/chitosan polyelectrolyte complexes for biomedical applications

被引:37
作者
Alsharabasy, Amir M. [1 ]
Moghannem, Saad A. [2 ]
El-Mazny, Waleed N. [3 ]
机构
[1] Natl Ctr Radiat Res & Technol, 5 Ahmed Alzomor St, Cairo 94089, Egypt
[2] Al Azhar Univ, Fac Sci, Cairo, Egypt
[3] Holding Co Biol Prod & Vaccines VACSERA, Giza, Egypt
关键词
Alginate; chitosan; polyelectrolyte complex; coacervation; wound healing; CHITOSAN; HYDROGELS; XANTHAN; PROLIFERATION; ALGINATE;
D O I
10.1177/0885328215613886
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Polyelectrolyte complexes represent a special class of polymeric compounds consisting of stoichiometric equivalents of oppositely charged polyions interacting together spontaneously to yield a complex in different forms. The present study aimed at preparing coacervates of alginate and chitosan polymers ready for casting as wound dressing films. This was based on controlling the pH of solutions and the reactions speed through controlling the rate of mixing of the polymers solutions together without using any water-miscible solvents. Alginate was modified with radiation and oxidation, and the interactions of the resulting chains and chitosan chains were tested with FTIR spectroscopy and scanning of the resulting films with SEM. This work showed the ability to prepare a complex of highly connected polymeric chains for further biomedical applications. This complex in the form of hydrogel could enhance the proliferation of cells invitro and the healing efficiency with accelerating the wound closure rate as evidenced through the histological observations.
引用
收藏
页码:1071 / 1079
页数:9
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