Nickel-catalysed selective N-arylation or N,N′-diarylation of secondary diamines

被引：19
作者：
Brenner, E [1 ]
Schneider, R [1 ]
Fort, Y [1 ]
机构：
[1] Univ Nancy 1, UMR CNRS 7565, Fac Sci Synthese Organ & Reactivite, F-54506 Vandoeuvre Les Nancy, France
来源：
TETRAHEDRON | 2002年 / 58卷 / 34期
关键词：
N-arylation; N; '-diarylation; secondary diamines; nickel catalysis;
D O I：
10.1016/S0040-4020(02)00750-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The selective synthesis of N-aryl or N,N'-diaryl piperazines and trimethylene(bis)piperidines from the corresponding diamines and aryl chlorides using a catalyst combination of Ni(0) associated to 2,2'-bipyridine is described. The Ni/2,2'-bipyridine catalyst is also effective for the sequential arylation of piperazine. The preparation of novel and unsymmetrical 1,4-diaryl piperazines is reported. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：6913 / 6924
页数：12
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