The synthesis and antitumor evaluation of unsymmetrical bis-imides

被引：19

作者：

Cherney, RJ

Swartz, SG

Patten, AD

Akamike, E

Sun, JH

Kaltenbach, RF

Seitz, SP

Behrens, CH

Getahun, Z

Trainor, GL

Vavala, M

Kirshenbaum, MR

Papp, LM

Stafford, MP

Czerniak, PM

Diamond, RJ

McRipley, RJ

Page, RJ

Gross, JL

机构：

[1] DuPont Merck Pharmaceutical Co. E., Wilmington

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(96)00591-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Unsymmetrical bis-imides 1 were synthesized and evaluated as potential antitumor agents. These novel bis-imides were assessed using three criteria: in vitro cytotoxicity (L1210), in vitro DNA binding, and in vivo studies with human tumor xenografts in mice. These studies identified DMP 315 as a potent, water soluble antitumor agent. (C) 1997, Elsevier Science Ltd.

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页码：163 / 168

页数：6

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