In vivo pharmacokinetics of phosphorothioate oligonucleotides containing contiguous guanosines

被引：27
作者：
Agrawal, S
Tan, WT
Cai, QY
Xie, XW
Zhang, RW
机构：
[1] UNIV ALABAMA,DIV CLIN PHARMACOL,BIRMINGHAM,AL 35294
[2] UNIV ALABAMA,DEPT PHARMACOL & TOXICOLOTY,BIRMINGHAM,AL 35294
来源：
ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT | 1997年 / 7卷 / 03期
关键词：
D O I：
10.1089/oli.1.1997.7.245
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：245 / 249
页数：5
相关论文
共 19 条
[1]   PHARMACOKINETICS, BIODISTRIBUTION, AND STABILITY OF OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATES IN MICE [J].
AGRAWAL, S ;
TEMSAMANI, J ;
TANG, JY .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (17) :7595-7599
[2]   Effect of G-rich sequences on the synthesis, purification, hybridization, cell uptake, and hemolytic activity of oligonucleotides [J].
Agrawal, S ;
Iadarola, PL ;
Temsamani, J ;
Zhao, QY ;
Shaw, DR .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (18) :2219-2224
[3]   Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: In vitro and in vivo studies [J].
Agrawal, S ;
Jiang, ZW ;
Zhao, QY ;
Shaw, D ;
Cai, QY ;
Roskey, A ;
Channavajjala, L ;
Saxinger, C ;
Zhang, RW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (06) :2620-2625
[4]   Antisense oligonucleotides: Towards clinical trials [J].
Agrawal, S .
TRENDS IN BIOTECHNOLOGY, 1996, 14 (10) :376-387
[5]   ABSORPTION, TISSUE DISTRIBUTION AND IN-VIVO STABILITY IN RATS OF A HYBRID ANTISENSE OLIGONUCLEOTIDE FOLLOWING ORAL-ADMINISTRATION [J].
AGRAWAL, S ;
ZHANG, XS ;
LU, ZH ;
ZHAO, H ;
TAMBURIN, JM ;
YAN, YM ;
CAI, HY ;
DIASIO, RB ;
HABUS, I ;
JIANG, ZW ;
IYER, RP ;
YU, D ;
ZHANG, RW .
BIOCHEMICAL PHARMACOLOGY, 1995, 50 (04) :571-576
[6]   PHARMACOKINETICS OF ANTISENSE OLIGONUCLEOTIDES [J].
AGRAWAL, S ;
TEMSAMANI, J ;
GALBRAITH, W ;
TANG, JY .
CLINICAL PHARMACOKINETICS, 1995, 28 (01) :7-16
[7]  
AGRAWAL S, 1996, ANTISENSE OLIGONUCLE, P60
[8]   In vivo studies with antisense oligonucleotides [J].
Akhtar, S ;
Agrawal, S .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1997, 18 (01) :12-18
[9]  
COSSUM PA, 1993, J PHARMACOL EXP THER, V267, P1181
[10]   PHARMACOKINETICS OF AN ANTISENSE PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDE AGAINST REV FROM HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 IN THE ADULT MALE-RAT FOLLOWING SINGLE INJECTIONS AND CONTINUOUS-INFUSION [J].
IVERSEN, PL ;
MATA, J ;
TRACEWELL, WG ;
ZON, G .
ANTISENSE RESEARCH AND DEVELOPMENT, 1994, 4 (01) :43-52
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