Urea bonded cyclodextrin derivatives onto silica for chiral HPLC

被引：64
作者：
Muderawan, I. Wayan
Ong, Teng-Teng
Ng, Siu-Choon [1 ]
机构：
[1] Nanyang Technol Univ, Div Chem & Biomol Engn, Singapore 637722, Singapore
[2] Chiral Sci & Technol Pte Ltd, Singapore, Singapore
来源：
JOURNAL OF SEPARATION SCIENCE | 2006年 / 29卷 / 12期
关键词：
chiral stationary phases; enantioseparation; high performance liquid chromatography; perfunctionalised cyclodextrin; urea linkage;
D O I：
10.1002/jssc.200500491
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Several structurally well-defined perfunctionalised cyclodextrin chiral stationary phases (CD CSPs) for high performance liquid chromatography have been successfully prepared by immobilisation of perfunctionalised cyclodextrins on silica through urea linkage(s) using the Staudinger reaction. These CSPs show high chiral recognition efficiency and are utilised in the resolution of various types of racemic compounds. This paper reviews the development of sixteen perfunctionalised cyclodextrin-based CSPs, their preparation, and their application to enantioseparation of seventy-seven racemic compounds under a range of separation conditions.
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收藏
页码：1849 / 1871
页数：23
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