Specificity and versatility in erythromycin biosynthesis

被引：9
作者：
Pieper, R
Kao, C
Khosla, C
Luo, GL
Cane, DE
机构：
[1] STANFORD UNIV,DEPT CHEM ENGN,STANFORD,CA 94305
[2] BROWN UNIV,DEPT CHEM,PROVIDENCE,RI 02912
来源：
CHEMICAL SOCIETY REVIEWS | 1996年 / 25卷 / 05期
关键词：
D O I：
10.1039/cs9962500297
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
6-Deoxyerythronolide B synthase is a modular polyketide synthase consisting of three large, multienzyme proteins with at least 28 distinct active sites that together catalyse the formation of 6-deoxyerythronolide B, the parent macrolide of the medicinally important erythromycin family of broad spectrum antibiotics. The combined use of molecular genetic and enzyme mechanistic tools has provided exciting new insights into the organization and function of these fascinating catalysts and allowed the rational generation of novel 'unnatural' natural products.
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页码：297 / &
页数：7
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