Regulation of NADPH Oxidases by G Protein-Coupled Receptors

被引:24
作者
Petry, Andreas [1 ]
Goerlach, Agnes [1 ,2 ]
机构
[1] Tech Univ Munich, German Heart Ctr Munich, Expt & Mol Pediat Cardiol, Lazarettstr 36, D-80636 Munich, Germany
[2] DZHK German Ctr Cardiovasc Res, Munich Heart Alliance, Partner Site Munich, Munich, Germany
关键词
GPCR; NOX; p22phox; receptors; activation; SMOOTH-MUSCLE-CELLS; NUCLEOTIDE EXCHANGE FACTOR; REDOX-DEPENDENT REGULATION; FACTOR-KAPPA-B; INDUCED SUPEROXIDE-PRODUCTION; OXYGEN SPECIES GENERATION; HETEROTRIMERIC G-PROTEINS; PROLINE-RICH REGION; BETA-GAMMA-SUBUNITS; SMALL GTPASE RAC;
D O I
10.1089/ars.2018.7525
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Significance: G protein-coupled receptors (GPCR) are the largest group of cell surface receptors, which link cells to their environment. Reactive oxygen species (ROS) can act as important cellular signaling molecules. The family of NADPH oxidases generates ROS in response to activated cell surface receptors. Recent Advances: Various signaling pathways linking GPCRs and activation of NADPH oxidases have been characterized. Critical Issues: Still, a more detailed analysis of G proteins involved in the GPCR-mediated activation of NADPH oxidases is needed. In addition, a more precise discrimination of NADPH oxidase activation due to either upregulation of subunit expression or posttranslational subunit modifications is needed. Also, the role of noncanonical modulators of NADPH oxidase activation in the response to GPCRs awaits further analyses. Future Directions: As GPCRs are one of the most popular classes of investigational drug targets, further detailing of G protein-coupled mechanisms in the activation mechanism of NADPH oxidases as well as better understanding of the link between newly identified NADPH oxidase interaction partners and GPCR signaling will provide new opportunities for improved efficiency and decreased off target effects of therapies targeting GPCRs.
引用
收藏
页码:74 / 94
页数:21
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