Regulation of NADPH Oxidases by G Protein-Coupled Receptors

被引:24
作者
Petry, Andreas [1 ]
Goerlach, Agnes [1 ,2 ]
机构
[1] Tech Univ Munich, German Heart Ctr Munich, Expt & Mol Pediat Cardiol, Lazarettstr 36, D-80636 Munich, Germany
[2] DZHK German Ctr Cardiovasc Res, Munich Heart Alliance, Partner Site Munich, Munich, Germany
关键词
GPCR; NOX; p22phox; receptors; activation; SMOOTH-MUSCLE-CELLS; NUCLEOTIDE EXCHANGE FACTOR; REDOX-DEPENDENT REGULATION; FACTOR-KAPPA-B; INDUCED SUPEROXIDE-PRODUCTION; OXYGEN SPECIES GENERATION; HETEROTRIMERIC G-PROTEINS; PROLINE-RICH REGION; BETA-GAMMA-SUBUNITS; SMALL GTPASE RAC;
D O I
10.1089/ars.2018.7525
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Significance: G protein-coupled receptors (GPCR) are the largest group of cell surface receptors, which link cells to their environment. Reactive oxygen species (ROS) can act as important cellular signaling molecules. The family of NADPH oxidases generates ROS in response to activated cell surface receptors. Recent Advances: Various signaling pathways linking GPCRs and activation of NADPH oxidases have been characterized. Critical Issues: Still, a more detailed analysis of G proteins involved in the GPCR-mediated activation of NADPH oxidases is needed. In addition, a more precise discrimination of NADPH oxidase activation due to either upregulation of subunit expression or posttranslational subunit modifications is needed. Also, the role of noncanonical modulators of NADPH oxidase activation in the response to GPCRs awaits further analyses. Future Directions: As GPCRs are one of the most popular classes of investigational drug targets, further detailing of G protein-coupled mechanisms in the activation mechanism of NADPH oxidases as well as better understanding of the link between newly identified NADPH oxidase interaction partners and GPCR signaling will provide new opportunities for improved efficiency and decreased off target effects of therapies targeting GPCRs.
引用
收藏
页码:74 / 94
页数:21
相关论文
共 219 条
[41]   Endothelin (ET)-1 inhibits nicotinamide adenine dinucleotide phosphate oxidase activity in human abdominal aortic endothelial cells:: A novel function of ETB1 receptors [J].
Dammanahalli, Jagadeesha K. ;
Sun, Zhongjie .
ENDOCRINOLOGY, 2008, 149 (10) :4979-4987
[42]   Phosphorylation of the NADPH oxidase component p67PHOX by ERK2 and P38MAPK:: Selectivity of phosphorylated sites and existence of an intramolecular regulatory domain in the tetratricopeptide-rich region [J].
Dang, PMC ;
Morel, F ;
Gougerot-Pocidalo, MA ;
El Benna, J .
BIOCHEMISTRY, 2003, 42 (15) :4520-4526
[43]   Protein kinase C ξ phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burst [J].
Dang, PMC ;
Fontayne, A ;
Hakim, J ;
El Benna, J ;
Périanin, A .
JOURNAL OF IMMUNOLOGY, 2001, 166 (02) :1206-1213
[44]   Poldip2 controls vascular smooth muscle cell migration by regulating focal adhesion turnover and force polarization [J].
Datla, Srinivasa Raju ;
McGrail, Daniel J. ;
Vukelic, Sasa ;
Huff, Lauren P. ;
Lyle, Alicia N. ;
Pounkova, Lily ;
Lee, Minyoung ;
Seidel-Rogol, Bonnie ;
Khalil, Mazen K. ;
Hilenski, Lula L. ;
Terada, Lance S. ;
Dawson, Michelle R. ;
Lassegue, Bernard ;
Griendling, Kathy K. .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2014, 307 (07) :H945-H957
[45]   The NOXO1β PX Domain Preferentially Targets PtdIns(4,5)P2 and PtdIns(3,4,5)P3 [J].
Davis, Nicole Y. ;
McPhail, Linda C. ;
Horita, David A. .
JOURNAL OF MOLECULAR BIOLOGY, 2012, 417 (05) :440-453
[46]   Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family [J].
De Deken, X ;
Wang, DT ;
Many, MC ;
Costagliola, S ;
Libert, F ;
Vassart, G ;
Dumont, JE ;
Miot, F .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (30) :23227-23233
[47]   Voltage-Gated Proton Channels Find Their Dream Job Managing the Respiratory Burst in Phagocytes [J].
DeCoursey, Thomas E. .
PHYSIOLOGY, 2010, 25 (01) :27-40
[48]   Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and Thrombosis [J].
Delaney, M. Keegan ;
Kim, Kyungho ;
Estevez, Brian ;
Xu, Zheng ;
Stojanovic-Terpo, Aleksandra ;
Shen, Bo ;
Ushio-Fukai, Masuko ;
Cho, Jaehyung ;
Du, Xiaoping .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2016, 36 (05) :846-854
[49]   Tks5-Dependent, Nox-Mediated Generation of Reactive Oxygen Species Is Necessary for Invadopodia Formation [J].
Diaz, Begona ;
Shani, Gidon ;
Pass, Ian ;
Anderson, Diana ;
Quintavalle, Manuela ;
Courtneidge, Sara A. .
SCIENCE SIGNALING, 2009, 2 (88) :ra53
[50]   ROS Production via P2Y1-PKC-NOX2 Is Triggered by Extracellular ATP after Electrical Stimulation of Skeletal Muscle Cells [J].
Diaz-Vegas, Alexis ;
Campos, Cristian A. ;
Contreras-Ferrat, Ariel ;
Casas, Mariana ;
Buvinic, Sonja ;
Jaimovich, Enrique ;
Espinosa, Alejandra .
PLOS ONE, 2015, 10 (06)