JmjC histone demethylases act as chromatin oxygen sensors

被引：15
作者：
Batie, Michael [1 ]
Rocha, Sonia [1 ]
机构：
[1] Univ Liverpool, Inst Integrat Biol, Dept Biochem, Biosci Bldg,Crown St, Liverpool L69 7ZB, Merseyside, England
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2019年 / 6卷 / 04期
基金：
英国惠康基金;
关键词：
Hypoxia; JmjC-histone demethylases; chromatin; HIF; transcription;
D O I：
10.1080/23723556.2019.1608501
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Oxygen sensing is important in physiology but also in disease. We find that hypoxia (oxygen deficiency) triggers rapid and hypoxia-inducible factor (HIF)-independent histone methylation changes which are reversible upon reoxygenation. Hypoxia-induced histone methylation genomic distribution precedes transcriptional changes and is mimicked by specific Jumonji-C (JmjC) histone demethylase depletion. Oxygen sensing by JmjC histone demethylases is required for the cellular response to hypoxia.
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页数：3
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