GAGA Protein is Essential for Male Germ Cell Development in Drosophila

被引：13

作者：

Dorogova, Natalia V. ^{[1
]}

Fedorova, Elena V. ^{[1
]}

Bolobolova, Elena Us. ^{[1
]}

Ogienko, Anna A. ^{[1
]}

Baricheva, Elina M. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia

来源：

GENESIS | 2014年 / 52卷 / 08期

基金：

俄罗斯基础研究基金会;

关键词：

germ cell migration; spermatogenesis; mitochondria; autophagy; Trl mutation; TRITHORAX-LIKE GENE; NORMAL MITOCHONDRIAL DYNAMICS; MOLECULAR CHAPERONES; QUALITY-CONTROL; HSP70; PROMOTER; HEAT-SHOCK; TRANSCRIPTION; AUTOPHAGY; EXPRESSION; MIGRATION;

D O I：

10.1002/dvg.22789

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Drosophila Trithorax-like (Trl) gene encodes a GAGA factor which regulates a number of developmentally important genes. In this study, we identify a new function for Drosophila GAGA factor in male germ cell development. Trl mutants carrying strong hypomorphic alleles display loss of primordial germ cells during their migration in embryogenesis and severe disruption in mitochondria structure during early spermatogenesis. The mutation resulted in small testes formation, a deficit of germ cells, abnormal mitochondrial morphogenesis, spermatocyte death through autophagy, and partial or complete male sterility. Pleiotropic mutation effects can be explained by the misexpression of GAGA factor target genes, the products of which are required for germ cell progression into mature sperm. (C) 2014 Wiley Periodicals, Inc.

引用

页码：738 / 751

页数：14

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