Highly Enantioselective and Diastereoselective Synthesis of Chiral Amino Alcohols by Ruthenium-Catalyzed Asymmetric Hydrogenation of α-Amino Aliphatic Ketones

被引：71
|
作者：
Xie, Jian-Hua
Liu, Sheng
Kong, Wei-Ling
Bai, Wen-Ju
Wang, Xiao-Chen
Wang, Li-Xin
Zhou, Qi-Lin [1 ]
机构：
[1] Nankai Univ, State Key Lab, Tianjin 300071, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 12期
关键词：
DYNAMIC KINETIC RESOLUTION; BETA-HYDROXY ESTERS; STEREOSELECTIVE HYDROGENATION; DERIVATIVES; RHODIUM; ROUTE;
D O I：
10.1021/ja901058u
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly efficient asymmetric hydrogenation of racemic acyclic alpha-amino aliphatic ketones via dynamic kinetic resolution has been realized, providing chiral amino alcohols in excellent enantioselectivities and diastereoselectivities. A hydrogen-bonding transition state mode was proposed for explaining the high diastereoselectivity and enantioselectivity of the reaction.
引用
收藏
页码：4222 / +
页数：3
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