Interstitial fluid homeostasis and pressure: news from the black box

被引:16
作者
Titze, Jens [1 ,2 ,3 ]
机构
[1] Vanderbilt Univ, Div Clin Pharmacol, Nashville, TN 37232 USA
[2] Univ Erlangen Nurnberg, Interdisciplinary Ctr Clin Res, Jr Res Grp 2, D-91054 Erlangen, Germany
[3] Univ Erlangen Nurnberg, Dept Hypertens & Nephrol, D-91054 Erlangen, Germany
关键词
VOLUME;
D O I
10.1038/ki.2013.287
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Extracellular volume expansion may lead to elevated blood pressure. This long-term adaptation of the vascular bed to extracellular volume overload is considered a multifactorial and not perfectly understood 'autoregulatory' event, which is difficult to measure. In this issue, Ebah and colleagues demonstrate a direct relationship between fluid overload and pressure in CKD patients. Surprise, instead of intravascular volume, interstitial fluids and pressures were measured. Finally!
引用
收藏
页码:869 / 871
页数:3
相关论文
共 10 条
[1]   Oncotic pressures opposing filtration across non-fenestrated rat microvessels [J].
Adamson, RH ;
Lenz, JE ;
Zhang, X ;
Adamson, GN ;
Weinbaum, S ;
Curry, FE .
JOURNAL OF PHYSIOLOGY-LONDON, 2004, 557 (03) :889-907
[2]   Subcutaneous interstitial pressure and volume characteristics in renal impairment associated with edema [J].
Ebah, Leonard M. ;
Wiig, Helge ;
Dawidowska, Idalia ;
O'Toole, Charlotte ;
Summers, Angela ;
Nikam, Milind ;
Jayanti, Anuradha ;
Coupes, Beatrice ;
Brenchley, Paul ;
Mitra, Sandip .
KIDNEY INTERNATIONAL, 2013, 84 (05) :980-988
[3]   INTERSTITIAL FLUID PRESSURE .2. PRESSURE-VOLUME CURVES OF INTERSTITIAL SPACE [J].
GUYTON, AC .
CIRCULATION RESEARCH, 1965, 16 (05) :452-&
[4]   Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism [J].
Machnik, Agnes ;
Neuhofer, Wolfgang ;
Jantsch, Jonathan ;
Dahlmann, Anke ;
Tammela, Tuomas ;
Machura, Katharina ;
Park, Joon-Keun ;
Beck, Franz-Xaver ;
Mueller, Dominik N. ;
Derer, Wolfgang ;
Goss, Jennifer ;
Ziomber, Agata ;
Dietsch, Peter ;
Wagner, Hubertus ;
van Rooijen, Nico ;
Kurtz, Armin ;
Hilgers, Karl F. ;
Alitalo, Kari ;
Eckardt, Kai-Uwe ;
Luft, Friedrich C. ;
Kerjaschki, Dontscho ;
Titze, Jens .
NATURE MEDICINE, 2009, 15 (05) :545-552
[5]   Dendritic-cell trafficking to lymph nodes through lymphatic vessels [J].
Randolph, GJ ;
Angeli, V ;
Swartz, MA .
NATURE REVIEWS IMMUNOLOGY, 2005, 5 (08) :617-628
[6]   BLOCKADE OF BETA(1)-INTEGRINS IN SKIN CAUSES EDEMA THROUGH LOWERING OF INTERSTITIAL FLUID PRESSURE [J].
REED, RK ;
RUBIN, K ;
WIIG, H ;
RODT, SA .
CIRCULATION RESEARCH, 1992, 71 (04) :978-983
[7]   MICROLYMPHATICS AND LYMPH-FLOW [J].
SCHMIDSCHONBEIN, GW .
PHYSIOLOGICAL REVIEWS, 1990, 70 (04) :987-1028
[8]  
Starling E H, 1896, J Physiol, V19, P312
[9]   Lymphangiogenesis: Molecular Mechanisms and Future Promise [J].
Tammela, Tuomas ;
Alitalo, Kari .
CELL, 2010, 140 (04) :460-476
[10]   INTERSTITIAL FLUID AND LYMPH FORMATION AND TRANSPORT: PHYSIOLOGICAL REGULATION AND ROLES IN INFLAMMATION AND CANCER [J].
Wiig, Helge ;
Swartz, Melody A. .
PHYSIOLOGICAL REVIEWS, 2012, 92 (03) :1005-1060