Phenolic compounds with IL-6 inhibitory activity from Aster yomena

被引：46

作者：

Kim, A. Ryun ^{[1
]}

Jin, Qinglong ^{[1
]}

Jin, Hong-Guang ^{[1
]}

Ko, Hae Ju ^{[1
]}

Woo, Eun-Rhan ^{[1
]}

机构：

[1] Chosun Univ, Coll Pharm, Kwangju 501759, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2014年 / 37卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

Aster yomena Makino; Asteraceae; Asteryomenin; IL-6 inhibitory activity; STELLERA-CHAMAEJASME L; INTERLEUKIN-6; MAKINO;

D O I：

10.1007/s12272-013-0236-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new biflavonoid, named asteryomenin (1), as well as six known phenolic compounds, esculetin (2), 4-O-beta-d-glucopyranoside-3-hydroxy methyl benzoate (3), caffeic acid (4), isoquercitrin (5), isorhamnetin-3-O-glucoside (6), and apigenin (7) were isolated from the aerial parts of Aster yomena. The structures of compounds (1-7) were identified based on 1D and 2D NMR, including H-1-H-1 COSY, HSQC, HMBC and NOESY spectroscopic analyses. Compounds 2-7 were isolated from this plant for the first time. For these isolates, the inhibitory activity of IL-6 production in the TNF-alpha stimulated MG-63 cell was examined. Among these isolates, compounds 4 and 7 appeared to have potent inhibitory activity of IL-6 production in the TNF-alpha stimulated MG-63 cell, while compounds 1-3 and 5-6 showed moderate activity.

引用

页码：845 / 851

页数：7

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