Development of approaches to a third-generation carbohydrate-conjugate vaccine against Streptococcus pneumoniae: the search for optimal oligosaccharide ligands

被引：34
作者：
Gening, M. L. [1 ]
Kurbatova, E. A. [2 ]
Tsvetkov, Yu E. [1 ]
Nifantiev, N. E. [1 ]
机构：
[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia
[2] II Mechnikov Res Inst Vaccines & Sera, Moscow 105064, Russia
来源：
RUSSIAN CHEMICAL REVIEWS | 2015年 / 84卷 / 11期
基金：
俄罗斯科学基金会;
关键词：
EXPERIMENTAL PNEUMOCOCCAL INFECTION; OPSONOPHAGOCYTIC KILLING RESPONSES; CAPSULE POLYSACCHARIDE CHAIN; REPEATING UNIT; SEROTYPE; 6D; CHEMOENZYMATIC SYNTHESIS; SYNTHETIC DISACCHARIDE; HUMAN-ANTIBODIES; TETRASACCHARIDE; FRAGMENTS;
D O I：
10.1070/RCR4574
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The review addresses the application of synthetic oligosaccharides related to fragments of capsular polysaccharides from different serotypes of the bacterium Streptococcus pneumoniae for the design of third-generation pneumococcal conjugate vaccines. Special focus is given to characteristic features of the chemical structures of oligosaccharides required for the induction of the protective immune response when using synthetic glycoconjugate vaccines based on oligosaccharide ligands and carrier proteins. The bibliography includes 101 references.
引用
收藏
页码：1100 / 1113
页数：14
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