The Role of Statins in Prevention of Preeclampsia: A Promise for the Future?

被引：20
作者：
Katsi, Vasiliki [1 ]
Georgountzos, Georgios [2 ]
Kallistratos, Manolis S. [3 ]
Zerdes, Ioannis [4 ]
Makris, Thomas [5 ]
Manolis, Athanasios J. [3 ]
Nihoyannopoulos, Petros [6 ]
Tousoulis, Dimitris [6 ]
机构：
[1] Hippokrateion Hosp, Dept Cardiol, Athens, Greece
[2] Univ Patras, Sch Med, Patras, Greece
[3] Asklepe Gen Hosp, Dept Cardiol, Athens, Greece
[4] Univ Ioannina, Sch Hlth Sci, Fac Med, Ioannina, Greece
[5] Elena Venizelou Hosp, Dept Cardiol, Athens, Greece
[6] Univ Athens, Hippokrat Hosp, Univ Dept Cardiol 1, Athens, Greece
来源：
FRONTIERS IN PHARMACOLOGY | 2017年 / 8卷
关键词：
preeclampsia; hypertension; statins; pravastatin; prevention; NITRIC-OXIDE SYNTHASE; MOUSE MODEL; REDUCTASE INHIBITORS; TYROSINE KINASE-1; HEME OXYGENASE-1; PRAVASTATIN; HYPERTENSION; PREGNANCY; RISK; DISEASE;
D O I：
10.3389/fphar.2017.00247
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Preeclampsia has been linked to high morbidity and mortality during pregnancy. However, no efficient pharmacological options for the prevention of this condition are currently available. Preeclampsia is thought to share several pathophysiologic mechanisms with cardiovascular disease, which has led to investigations for the potential role of statins (HMG CoA reductase inhibitors) in its prevention and early management. Pravastatin seems to have a safer pharmacokinetic profile compared to other statins, however, the existing preclinical evidence for its effectiveness in preeclampsia treatment has been mostly restricted to animal models. This review aims to summarize the current data and delineate the potential future role of statins in the prevention and management of preeclampsia.
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页数：6
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