Systems Medicine: A New Approach to Clinical Practice

被引：9
作者：
Cardinal-Fernandez, Pablo [1 ,2 ]
Nin, Nicolas [2 ,3 ]
Ruiz-Cabello, Jesus [2 ,4 ,5 ]
Lorente, Jose A. [1 ,2 ,6 ]
机构：
[1] Hosp Univ Getafe, Serv Med Intens, Madrid, Spain
[2] CIBER Enfermedades Resp, Madrid, Spain
[3] Hosp Univ Torrejon, Serv Med Intens, Madrid, Spain
[4] CNIC, Madrid, Spain
[5] Univ Complutense Madrid, Madrid, Spain
[6] Univ Europea Madrid, Madrid, Spain
来源：
ARCHIVOS DE BRONCONEUMOLOGIA | 2014年 / 50卷 / 10期
关键词：
Systems medicine; Systems biology; Pulmonary medicine; Acute respiratory failure; ACUTE LUNG INJURY; METABOLIC PATHWAYS; DOUBLE-BLIND; RECONSTRUCTION; GENOME; NETWORKS; BIOLOGY; ORGANIZATION; MODEL;
D O I：
10.1016/j.arbres.2013.10.010
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Most respiratory diseases are considered complex diseases as their susceptibility and outcomes are determined by the interaction between host-dependent factors (genetic factors, comorbidities, etc.) and environmental factors (exposure to microorganisms or allergens, treatments received, etc.) The reductionist approach in the study of diseases has been of fundamental importance for the understanding of the different components of a system. Systems biology or systems medicine is a complementary approach aimed at analyzing the interactions between the different components within one organizational level (genome, transcriptome, proteome), and then between the different levels. Systems medicine is currently used for the interpretation and understanding of the pathogenesis and pathophysiology of different diseases, biomarker discovery, design of innovative therapeutic targets, and the drawing up of computational models for different biological processes. In this review we discuss the most relevant concepts of the theory underlying systems medicine, as well as its applications in the various biological processes in humans. (C) 2013 SEPAR. Published by Elsevier Espana, S.L.U. All rights reserved.
引用
收藏
页码：444 / 451
页数：8
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