A BRIEF REVIEW OF THE ANTICANCER ACTIVITY OF α-AMINOPHOSPHONIC ACID DERIVATIVES AND A REPORT ON THE IN VITRO ACTIVITY OF SOME DIALKYL α-aryl- (OR HETEROARYL)-α-(DIPHENYLMETHYLAMINO)METHANEPHOSPHONATES

被引：15

作者：

Hudson, Harry R. ^{[1
]}

Lee, Rosalind J. ^{[1
]}

机构：

[1] London Metropolitan Univ, Fac Life Sci & Comp, London N7 8DB, England

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2014年 / 189卷 / 7-8期

关键词：

Aminophosphonic acid; aminophosphonate; anticancer; S-12363;

D O I：

10.1080/10426507.2014.905781

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Reports on the anticancer activity of representative alpha-aminophosphonic acid derivatives are briefly reviewed, with comments where possible on modes of action. Preliminary in vitro screening results are also presented for selected dialkyl alpha-aryl (or heteroaryl)-alpha-(diphenylmethylamino)methanephosphonates against the National Cancer Institute (NCI) 60-cell line panel of human tumor cells, which showed average response parameters for active compounds of GI(50) between 4.81 x 10(-6) and 2.40 x 10(-5) M, TGI between 1.88 and 6.28 x 10(-5) M, and LC50 between 5.71 and 9.37 x 10(-5) M. The highest activity was shown by the alpha-phenyl compound for which GI(50) 10(-7) M was recorded against leukemia cell line MOLT-4.

引用

页码：1149 / 1155

页数：7

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