Synthetic wavelength based phase unwrapping in spectral domain optical coherence tomography

被引:39
作者
Hendargo, Hansford C. [1 ]
Zhao, Mingtao [1 ]
Shepherd, Neal [2 ]
Izatt, Joseph A. [1 ]
机构
[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA
[2] Duke Univ, George & Jean Brumley Jr Neonatal Perrinatal Res, Div Neonatol, Dept Pediat,Med Ctr, Durham, NC 27710 USA
关键词
DIGITAL HOLOGRAPHY; 2-PI AMBIGUITY; MICROSCOPY; CONTRAST; REFLECTION; DYNAMICS;
D O I
10.1364/OE.17.005039
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
Phase sensing implementations of spectral domain optical coherence tomography (SDOCT) have demonstrated the ability to measure nanometer-scale temporal and spatial profiles of samples. However, the phase information suffers from a 2 pi ambiguity that limits observations of larger sample displacements to lengths less than half the source center wavelength. We introduce a synthetic wavelength phase unwrapping technique in SDOCT that uses spectral windowing and corrects the 2 pi ambiguity, providing accurate measurements of sample motion with information gained from standard SDOCT processing. We demonstrate this technique by using a common path implementation of SDOCT and correctly measure phase profiles from a phantom phase object and human epithelial cheek cells which produce multiple wrapping artifacts. Using a synthetic wavelength for phase unwrapping could prove useful in Doppler or other phase based implementations of OCT. (C) 2009 Optical Society of America
引用
收藏
页码:5039 / 5051
页数:13
相关论文
共 34 条
[1]   2-WAVELENGTH PHASE-SHIFTING INTERFEROMETRY [J].
CHENG, YY ;
WYANT, JC .
APPLIED OPTICS, 1984, 23 (24) :4539-4543
[2]   Spectral-domain phase microscopy [J].
Choma, MA ;
Ellerbee, AK ;
Yang, CH ;
Creazzo, TL ;
Izatt, JA .
OPTICS LETTERS, 2005, 30 (10) :1162-1164
[3]   Sensitivity advantage of swept source and Fourier domain optical coherence tomography [J].
Choma, MA ;
Sarunic, MV ;
Yang, CH ;
Izatt, JA .
OPTICS EXPRESS, 2003, 11 (18) :2183-2189
[4]   Doppler flow imaging of cytoplasmic streaming using spectral domain phase microscopy [J].
Choma, Michael A. ;
Ellerbee, Audrey K. ;
Yazdanfar, Siavash ;
Izatt, Joseph A. .
JOURNAL OF BIOMEDICAL OPTICS, 2006, 11 (02)
[5]   PHASE-SHIFTING SPECKLE INTERFEROMETRY [J].
CREATH, K .
APPLIED OPTICS, 1985, 24 (18) :3053-3058
[6]   Digital holography for quantitative phase-contrast imaging [J].
Cuche, E ;
Bevilacqua, F ;
Depeursinge, C .
OPTICS LETTERS, 1999, 24 (05) :291-293
[7]   Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography [J].
de Boer, JF ;
Cense, B ;
Park, BH ;
Pierce, MC ;
Tearney, GJ ;
Bouma, BE .
OPTICS LETTERS, 2003, 28 (21) :2067-2069
[8]   Effects of phase changes on reflection and their wavelength dependence in optical profilometry [J].
Doi, T ;
Toyoda, K ;
Tanimura, Y .
APPLIED OPTICS, 1997, 36 (28) :7157-7161
[9]   Investigating nanoscale cellular dynamics with cross-sectional spectral domain phase microscopy [J].
Ellerbee, Audrey K. ;
Creazzo, Tony L. ;
Izatt, Joseph A. .
OPTICS EXPRESS, 2007, 15 (13) :8115-8124
[10]   Phase retrieval in low-coherence interferometric microscopy [J].
Ellerbee, Audrey K. ;
Izatt, Joseph A. .
OPTICS LETTERS, 2007, 32 (04) :388-390