ICFSR Task Force Perspective on Biomarkers for Sarcopenia and Frailty

被引：35

作者：

Rodriguez-Manas, L. ^{[1
]}

De Carvalho, I. Araujo ^{[2
]}

Bhasin, S. ^{[3
]}

Bischoff-Ferrari, H. A. ^{[4
,5
]}

Cesari, M. ^{[6
]}

Evans, W. ^{[7
]}

Hare, J. M. ^{[8
]}

Pahor, M. ^{[9
]}

Parini, A. ^{[10
]}

Rolland, Y. ^{[11
]}

Fielding, R. A. ^{[12
]}

Walston, J. ^{[13
]}

Vellas, B. ^{[14
]}

机构：

[1] Hosp Univ Getafe, Serv Geriatria, Toledo, Spain

[2] WHO, Geneva, Switzerland

[3] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA

[4] Univ Hosp, Zurich, Switzerland

[5] Univ Zurich, Zurich, Switzerland

[6] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Milan, Italy

[7] Duke Univ, Med Ctr, Durham, NC USA

[8] Univ Miami, Miller Sch Med, Interdisciplinary Stem Cell Inst, Miami, FL 33136 USA

[9] Univ Florida, Inst Aging, Gainesville, FL USA

[10] CHU Toulouse, Inst Cardiovasc & Metab Dis, INSERM, U1048, Toulouse, France

[11] Hop La Crave, Clin Gerontopole, Serv Med Interne & Gerontol, Toulouse, France

[12] Tufts Univ, Boston, MA 02111 USA

[13] Johns Hopkins Div Geriatr Med & Gerontol, Baltimore, MD USA

[14] Toulouse Univ Hosp, Alzheimers Dis Res & Clin Ctr, INSERM, Gerontopole,U1027, Toulouse, France

来源：

JOURNAL OF FRAILTY & AGING | 2020年 / 9卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Frailty; sarcopenia; biomarkers; consensus; GROWTH-FACTOR-I; PHYSICAL FRAILTY; OPERATIONAL DEFINITION; SKELETAL-MUSCLE; OLDER-ADULTS; RATIONALE; TRIALS; INFLAMMATION; ASSOCIATION; TOLEDO;

D O I：

10.14283/jfa.2019.32

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Biomarkers of frailty and sarcopenia are essential to advance the understanding of these conditions of aging and develop new diagnostic tools and effective treatments. The International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force - a group of academic and industry scientists from around the world - met in February 2019 to discuss the current state of biomarker development for frailty and sarcopenia. The D3Cr dilution method, which assesses creatinine excretion as a biochemical measure of muscle mass, was suggested as a more accurate measure of functional muscle mass than assessment by dual energy x-ray absorptiometry (DXA). Proposed biomarkers of frailty include markers of inflammation, the hypothalamic-pituitary-adrenal (HPA) axis response to stress, altered glucose insulin dynamics, endocrine dysregulation, aging, and others, acknowledging the complex multisystem etiology that contributes to frailty. Lack of clarity regarding a regulatory pathway for biomarker development has hindered progress; however, there are currently several international efforts to develop such biomarkers as tools to improve the treatment of individuals presenting these conditions.

引用

页码：4 / 8

页数：5

共 51 条

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