YM155, a novel small molecule survivin suppressant, exhibits curative antitumor activities in experimental human malignant lymphoma models in vivo

被引：1
|
作者：
Kita, A.
Nakahara, T.
Yamanaka, K.
Koutoku, H.
Takeuchi, M.
Kinoyama, I.
Matsuhisa, A.
Sasamata, M.
机构：
[1] Astellas Pharma Inc, Pharmacol Res Labs, Tsukuba, Ibaraki, Japan
[2] Astellas Pharma Inc, Mol Med Res Labs, Tsukuba, Ibaraki, Japan
[3] Astellas Pharma Inc, Chem Res Labs, Tsukuba, Ibaraki, Japan
来源：
EJC SUPPLEMENTS | 2006年 / 4卷 / 12期
关键词：
D O I：
10.1016/S1359-6349(06)70382-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
377
引用
收藏
页码：116 / 116
页数：1
相关论文
共 46 条
  • [1] YM155: A Small Molecule Survivin Suppressant with Potent Antitumor Effect in Human Breast Cancer Models
    Kita, A.
    Nakahara, T.
    Yamanaka, K.
    Nakata, M.
    Kaneko, N.
    Koutoku, H.
    Sasamata, M.
    CANCER RESEARCH, 2009, 69 (24) : 692S - 693S
  • [2] YM155: a small molecule survivin suppressant with potent antitumor effect in human cancer xenograft models
    Kita, Aya
    Nakahara, Takahito
    Takeuchi, Masahiro
    Kinoyama, Isao
    Matsuhisa, Akira
    Yamanaka, Kentaro
    Nakata, Mari
    Kaneko, Naoki
    Koutoku, Hiroshi
    Sasamata, Masao
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, 112 : 32P - 32P
  • [3] Antitumor Activity of YM155, a Selective Small-Molecule Survivin Suppressant, Alone and in Combination with Docetaxel in Human Malignant Melanoma Models
    Yamanaka, Kentaro
    Nakahara, Takahito
    Yamauchi, Tomohiro
    Kita, Aya
    Takeuchi, Masahiro
    Kiyonaga, Fumiko
    Kaneko, Naoki
    Sasamata, Masao
    CLINICAL CANCER RESEARCH, 2011, 17 (16) : 5423 - 5431
  • [4] YM155, a novel survivin suppressant, induced downregulation of survivin and potent antitumor activities in experimental human prostate tumor xenograft models.
    Nakahara, T
    Takeuchi, M
    Isao, K
    Tsuyoshi, M
    Akira, M
    Kita, A
    Tominaga, F
    Yamanaka, K
    Sasamata, M
    CLINICAL CANCER RESEARCH, 2005, 11 (24) : 9082S - 9083S
  • [5] Tumor regression induced by YM155, a novel, small molecule survivin suppressant, in experimental human lung tumor models.
    Nakahara, Takahito
    Takeuchi, Masahiro
    Kinoyama, Isao
    Kita, Aya
    Yamanaka, Kentaro
    Matsuhisa, Akira
    Sasamata, Masao
    CANCER RESEARCH, 2006, 66 (08)
  • [6] Antitumor efficacy and biodistribution of liposomal sepantronium bromide (YM155), a novel small-molecule survivin suppressant
    Kawano, Hiroki
    Shakushiro, Kohsuke
    Nakata, Mari
    Kita, Aya
    Maeda, Atsushi
    Watanabe, Shunsuke
    Sako, Kazuhiro
    Oku, Naoto
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2014, 88 (01) : 283 - 289
  • [7] Antitumor effect of YM155, a novel small-molecule survivin suppressant, via mitochondrial apoptosis in human MFH/UPS
    Minoda, Masaya
    Kawamoto, Teruya
    Ueha, Takeshi
    Kamata, Etsuko
    Morishita, Masayuki
    Harada, Risa
    Toda, Mitsunori
    Onishi, Yasuo
    Hara, Hitomi
    Kurosaka, Masahiro
    Akisue, Toshihiro
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2015, 47 (03) : 891 - 899
  • [8] Antitumor effects of YM155, a novel survivin suppressant, against human aggressive non-Hodgkin lymphoma
    Kita, Aya
    Nakahara, Takahito
    Yamanaka, Kentaro
    Nakano, Kenji
    Nakata, Mari
    Mori, Masamichi
    Kaneko, Naoki
    Koutoku, Hiroshi
    Izumisawa, Nobuyuki
    Sasamata, Masao
    LEUKEMIA RESEARCH, 2011, 35 (06) : 787 - 792
  • [9] Broad spectrum and potent antitumor activities of YM155, a novel small-molecule survivin suppressant, in a wide variety of human cancer cell lines and xenograft models
    Nakahara, Takahito
    Kita, Aya
    Yamanaka, Kentaro
    Mori, Masamichi
    Amino, Nobuaki
    Takeuchi, Masahiro
    Tominaga, Fumiko
    Kinoyama, Isao
    Matsuhisa, Akira
    Kudou, Masafumi
    Sasamata, Masao
    CANCER SCIENCE, 2011, 102 (03) : 614 - 621
  • [10] Schedule-dependent antitumor activity of YM155, a novel small molecule survivin suppressant, in experimental human hormone refractory prostate carcinoma xenograft
    Nakahara, T
    Takeuchi, M
    Kinoyama, I
    Minematsu, T
    Matsuhisa, A
    Kita, A
    Tominaga, F
    Yamanaka, K
    Sasamata, M
    ANNALS OF ONCOLOGY, 2006, 17 : 38 - 38
12345