A mini review on the associations of matrix metalloproteinases (MMPs) -1, -8, -13 with periodontal disease

被引：14
作者：
Khuda, Fazle [1 ]
Anuar, Nur Najmi Mohamad [2 ]
Baharin, Badiah [3 ]
Nasruddin, Nurrul Shaqinah [1 ]
机构：
[1] Univ Kebangsaan Malaysia, Fac Dent, Dept Craniofacial Diagnost & Biosci, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
[2] Univ Kebangsaan Malaysia, Fac Hlth Sci, Ctr Toxicol & Hlth Risk Studies, Programme Biomed Sci, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
[3] Univ Kebangsaan Malaysia, Fac Dent, Dept Restorat Dent, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
来源：
AIMS MOLECULAR SCIENCE | 2021年 / 8卷 / 01期
关键词：
collagenase; matrix metalloproteinase; MMPs; periodontitis; periodontal disease; BIOLOGICAL FUNCTIONS; TISSUE INHIBITORS; FLUID; THERAPY; MMP-13; SALIVA;
D O I：
10.3934/molsci.2021002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Matrix metalloproteinases (MMPs) are one of the most important endopeptidases in periodontal disease that generally degrade extracellular matrix (ECM) components of periodontal supporting tissues, leading to tooth loss. Among the MMP family, MMP-1, -8 and -13, which are also known as the collagenase group, play a vital role in the degradation of ECM collagen and non-collagen substances. Elevated levels of MMP -1, -8 and -13 are markedly significant within tissue, gingival crevicular fluid (GCF), and saliva of patients with periodontitis, which help to explain the progression pattern of the disease. This review provides an overview of MMP -1, -8, and -13 on their structures, functions and their critical role in periodontitis.
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页码：13 / 31
页数：19
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