RETRACTED: Induction of apoptosis and inhibition of DNA topoisomerase-I in K-562 cells by a marine microalgal polysaccharide (Retracted Article. See vol 71, pg 2575, 2002)

被引：14

作者：

Sogawa, K

Yamada, T ^{[1
]}

Sumida, T

Hamakawa, H

Kuwabara, H

Matsuda, M

Muramatsu, Y

Kose, H

Matsumoto, K

Sasaki, Y

Okutani, K

Kondo, K

Monden, Y

机构：

[1] Kyoto Univ, Grad Sch Agr, Dept Anim Genet & Breeding, Sakyo Ku, Kyoto 6068502, Japan

[2] Univ Tokushima, Sch Med, Dept Surg 2, Tokushima 7700042, Japan

[3] Univ Tokushima, Sch Med, Inst Anim Experimentat, Tokushima 7700042, Japan

[4] Ehime Univ, Sch Med, Dept Oral Surg, Matsuyama, Ehime 7910204, Japan

[5] Kagawa Med Coll, Dept Pathol, Kagawa 7610701, Japan

[6] Kagawa Univ, Fac Agr, Dept Bioresource Sci, Kagawa 7610701, Japan

来源：

LIFE SCIENCES | 2000年 / 66卷 / 16期

关键词：

microalgal polysaccharide; apoptosis; topoisomerase-I; K562; cells;

D O I：

10.1016/S0024-3205(00)00473-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We have previously purified an extracellular polysaccharide, D-galactan sulfate associated with L(+)-lactic acid, produced from a marine microalga Dinoflagellate Gymnodinium sp. A(3) (GA3). The GA3 polysaccharide, irrespective of presence or absence of lactic acid, exhibited significant cytotoxicity, which is based on an induction of apoptotic cell death, toward human myeloid leukemia K562 cells. Furthermore, we found that the GA3 polysaccharide with or without lactic acid possesses an inhibitory effect on topoisomerase-I (topo-I). The potent cytotoxic effect of GA3 polysaccharide may result from its inhibitory effect on topo-I, because the topo-I inhibition is known to trigger apoptotic cell death. (C) 2000 Elsevier Science Inc.

引用

页码：PL227 / PL231

页数：5

共 8 条

[1] PRODUCTION OF A LACTATE-ASSOCIATED GALACTAN SULFATE BY A DINOFLAGELLATE GYMNODINIUM A(3) [J].