Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction

被引：21

作者：

Fan, Qiying ^{[1
]}

Mao, Hua ^{[1
]}

Angelini, Aude ^{[1
]}

Coarfa, Cristian ^{[2
,3
,4
]}

Robertson, Matthew J. ^{[2
,3
,4
]}

Lagor, William R. ^{[5
]}

Wehrens, Xander H. T. ^{[1
,5
,6
,7
,8
]}

Martin, James F. ^{[5
,9
,10
]}

Pi, Xinchun ^{[1
]}

Xie, Liang ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Med, Cardiovasc Res Inst, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol Biol, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Cellular Biol, Houston, TX 77030 USA

[4] Baylor Coll Med, Dan L Duncan Comprehens Canc Ctr, Ctr Precis Environm Hlth, Houston, TX 77030 USA

[5] Baylor Coll Med, Dept Mol Physiol & Biophys, Houston, TX 77030 USA

[6] Baylor Coll Med, Dept Med, Cardiovasc Res Inst, Houston, TX 77030 USA

[7] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[8] Baylor Coll Med, Ctr Space Med, Houston, TX 77030 USA

[9] Baylor Coll Med, Cardiovasc Res Inst, Program Dev Biol, Houston, TX 77030 USA

[10] Texas Heart Inst, Houston, TX 77025 USA

来源：

CIRCULATION | 2019年 / 140卷 / 05期

基金：

美国国家卫生研究院;

关键词：

cell proliferation; endothelial cells; heart failure; hypoxia; myocardial infarction; myocytes; cardiac; regeneration;

D O I：

10.1161/CIRCULATIONAHA.118.039276

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：440 / 442

页数：3

共 5 条

[1] Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2α [J].

Dai, Zhiyu ;

Li, Ming ;

Wharton, John ;

Zhu, Maggie M. ;

Zhao, You-Yang .

CIRCULATION, 2016, 133 (24) :2447-+

[2] Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway [J].

Kaelin, William G., Jr. ;

Ratcliffe, Peter J. .

MOLECULAR CELL, 2008, 30 (04) :393-402

[3] Hypoxia induces heart regeneration in adult mice [J].

Nakada, Yuji ;

Canseco, Diana C. ;

Thet, SuWannee ;

Abdisalaam, Salim ;

Asaithamby, Aroumougame ;

Santos, Celio X. ;

Shah, Ajay M. ;

Zhang, Hua ;

Faber, James E. ;

Kinter, Michael T. ;

Szweda, Luke I. ;

Xing, Chao ;

Hu, Zeping ;

Deberardinis, Ralph J. . ;

Schiattarella, Gabriele ;

Hill, Joseph A. ;

Oz, Orhan ;

Lu, Zhigang ;

Zhang, Cheng Cheng ;

Kimura, Wataru ;

Sadek, Hesham A. .

NATURE, 2017, 541 (7636) :222-+

[4] The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration [J].

Wang, Jun ;

Liu, Shijie ;

Heallen, Todd ;

Martin, James F. .

NATURE REVIEWS CARDIOLOGY, 2018, 15 (11) :672-684

[5] PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban [J].

Xie, Liang ;

Pi, Xinchun ;

Townley-Tilson, W. H. Davin ;

Li, Na ;

Wehrens, Xander H. T. ;

Entman, Mark L. ;

Taffet, George E. ;

Mishra, Ashutosh ;

Peng, Junmin ;

Schisler, Jonathan C. ;

Meissner, Gerhard ;

Patterson, Cam .

JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (07) :2759-2771

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