Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction

被引：21

作者：

Fan, Qiying ^{[1
]}

Mao, Hua ^{[1
]}

Angelini, Aude ^{[1
]}

Coarfa, Cristian ^{[2
,3
,4
]}

Robertson, Matthew J. ^{[2
,3
,4
]}

Lagor, William R. ^{[5
]}

Wehrens, Xander H. T. ^{[1
,5
,6
,7
,8
]}

Martin, James F. ^{[5
,9
,10
]}

Pi, Xinchun ^{[1
]}

Xie, Liang ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Med, Cardiovasc Res Inst, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol Biol, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Cellular Biol, Houston, TX 77030 USA

[4] Baylor Coll Med, Dan L Duncan Comprehens Canc Ctr, Ctr Precis Environm Hlth, Houston, TX 77030 USA

[5] Baylor Coll Med, Dept Mol Physiol & Biophys, Houston, TX 77030 USA

[6] Baylor Coll Med, Dept Med, Cardiovasc Res Inst, Houston, TX 77030 USA

[7] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[8] Baylor Coll Med, Ctr Space Med, Houston, TX 77030 USA

[9] Baylor Coll Med, Cardiovasc Res Inst, Program Dev Biol, Houston, TX 77030 USA

[10] Texas Heart Inst, Houston, TX 77025 USA

来源：

CIRCULATION | 2019年 / 140卷 / 05期

基金：

美国国家卫生研究院;

关键词：

cell proliferation; endothelial cells; heart failure; hypoxia; myocardial infarction; myocytes; cardiac; regeneration;

D O I：

10.1161/CIRCULATIONAHA.118.039276

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：440 / 442

页数：3

共 5 条

[1] Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2α
Dai, Zhiyu
Li, Ming
Wharton, John
Zhu, Maggie M.
Zhao, You-Yang
[J]. CIRCULATION, 2016, 133 (24) : 2447 - +
[2] Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
Kaelin, William G., Jr.
Ratcliffe, Peter J.
[J]. MOLECULAR CELL, 2008, 30 (04) : 393 - 402
[3] Hypoxia induces heart regeneration in adult mice
Nakada, Yuji
Canseco, Diana C.
Thet, SuWannee
Abdisalaam, Salim
Asaithamby, Aroumougame
Santos, Celio X.
Shah, Ajay M.
Zhang, Hua
Faber, James E.
Kinter, Michael T.
Szweda, Luke I.
Xing, Chao
Hu, Zeping
Deberardinis, Ralph J. .
Schiattarella, Gabriele
Hill, Joseph A.
Oz, Orhan
Lu, Zhigang
Zhang, Cheng Cheng
Kimura, Wataru
Sadek, Hesham A.
[J]. NATURE, 2017, 541 (7636) : 222 - +
[4] The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration
Wang, Jun
Liu, Shijie
Heallen, Todd
Martin, James F.
[J]. NATURE REVIEWS CARDIOLOGY, 2018, 15 (11) : 672 - 684
[5] PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban
Xie, Liang
Pi, Xinchun
Townley-Tilson, W. H. Davin
Li, Na
Wehrens, Xander H. T.
Entman, Mark L.
Taffet, George E.
Mishra, Ashutosh
Peng, Junmin
Schisler, Jonathan C.
Meissner, Gerhard
Patterson, Cam
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (07) : 2759 - 2771

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