Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)nOCH2 linkers between pyridinium rings and their reactivity against VX

被引：29
作者：
Oh, Kyung-Ae
Yang, Yeol
Jun, Daniel
Kuca, Kamil
Jung, Young-Sik
机构：
[1] Korea Res Inst Chem Technol, Div Med Sci, Taejon 305606, South Korea
[2] Fac Mil Hlth Sci, Dept Toxicol, Hradec Kralove, Czech Republic
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 18期
关键词：
organophosphorus nerve agents; bis-pyridiumaldoxime reactivators; acetylcholinesterase; linker;
D O I：
10.1016/j.bmcl.2006.06.063
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New bis-pyridinium oxime reactivators connected with CH2O(CH2)(n)OCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent. Among the prepared compounds, 1,2-dimethoxy-ethylene-bis-N,N'-4-pyridiumaldoxime dichloride 5a was the most potent and appeared to be the most promising compound as a potential reactivator for AChE inhibited by organophosphorus VX agent. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4852 / 4855
页数：4
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