Development and optimization of pH-responsive PLGA-chitosan nanoparticles for triggered release of antimicrobials

被引：43

作者：

Pola, Cicero C. ^{[1
,2
,5
]}

Moraes, Allan R. F. ^{[3
]}

Medeiros, Eber A. A. ^{[1
]}

Teofilo, Reinaldo F. ^{[4
]}

Soares, Nilda F. F. ^{[1
]}

Gomes, Carmen L. ^{[2
,5
]}

机构：

[1] Univ Fed Vicosa, Dept Food Technol, BR-36570900 Vicosa, MG, Brazil

[2] Texas A&M Univ, Dept Biol & Agr Engn, College Stn, TX 77843 USA

[3] Univ Fed Vicosa, Inst Agr Sci, BR-38810000 Rio Paranaiba, MG, Brazil

[4] Univ Fed Vicosa, Dept Chem, BR-36570900 Vicosa, MG, Brazil

[5] Iowa State Univ, Dept Mech Engn, 1620F Howe Hall, Ames, IA 50011 USA

来源：

FOOD CHEMISTRY | 2019年 / 295卷

关键词：

PLGA-chitosan nanoparticles; Encapsulation; pH-sensitive release; Antibacterial activity; Controlled release; CO-GLYCOLIDE PLGA; DELIVERY-SYSTEMS; ESSENTIAL OILS; ANTIBACTERIAL ACTIVITY; ESCHERICHIA-COLI; ALPHA-TOCOPHEROL; DRUG-DELIVERY; ANTIOXIDANT; NANOENCAPSULATION; PHYTOCHEMICALS;

D O I：

10.1016/j.foodchem.2019.05.165

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The aim of this work was to develop and optimize a pH-responsive nanoparticle based on poly(D, L-lactide-co-glycolide) (PLGA) and chitosan (CHIT) for delivery of natural antimicrobial using trans-cinnamaldehyde (TCIN) as a model compound. The optimization was performed using a central composite design and the desirability function approach. The optimized levels of variables considering all significant responses were 4% (w/w) of TCIN and 6.75% (w/w) of CHIT. After, optimized nanoparticles were produced and characterized according to their physicochemical properties and their antimicrobial activity against Salmonella Typhimurium and Staphylococcus aureus. Optimized nanoparticles characterization indicated a satisfactory TCIN encapsulation (33.20 +/- 0.85%), spherical shape, pH-responsive controlled release, with faster release in the presence of CHIT at low pH, and enhanced antimicrobial activity against both pathogens. TCIN encapsulation using PLGA coated with CHIT enhanced its antimicrobial activity and generated a delivery system with pH-sensitivity for controlled release with promising properties for food safety applications.

引用

页码：671 / 679

页数：9

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