Anti-Inflammatory Effects of GLP-1-Based Therapies beyond Glucose Control

被引：281

作者：

Lee, Young-Sun ^{[1
]}

Jun, Hee-Sook ^{[1
,2
,3
,4
]}

机构：

[1] Gachon Univ, Lee Gil Ya Canc & Diabet Inst, Yeonsu Ku, 7-45 Songdo Dong, Inchon 406840, South Korea

[2] Gachon Univ, Coll Pharm, Yeonsu Ku, 7-45 Songdo Dong, Inchon 406840, South Korea

[3] Gachon Univ, Gachon Inst Pharmaceut Sci, Yeonsu Ku, 7-45 Songdo Dong, Inchon 406840, South Korea

[4] Gil Hosp, Gachon Med Res Inst, Inchon 405760, South Korea

来源：

MEDIATORS OF INFLAMMATION | 2016年 / 2016卷

基金：

新加坡国家研究基金会;

关键词：

GLUCAGON-LIKE PEPTIDE-1; LOW-GRADE INFLAMMATION; DIPEPTIDYL PEPTIDASE-4 INHIBITOR; RECEPTOR AGONIST EXENATIDE; NECROSIS-FACTOR-ALPHA; FATTY LIVER-DISEASE; BETA-CELL FUNCTION; NF-KAPPA-B; GLP-1; RECEPTOR; INSULIN-RESISTANCE;

D O I：

10.1155/2016/3094642

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Glucagon-like peptide-1 (GLP-1) is an incretin hormone mainly secreted from intestinal L cells in response to nutrient ingestion. GLP-1 has beneficial effects for glucose homeostasis by stimulating insulin secretion from pancreatic beta-cells, delaying gastric emptying, decreasing plasma glucagon, reducing food intake, and stimulating glucose disposal. Therefore, GLP-1-based therapies such as GLP-1 receptor agonists and inhibitors of dipeptidyl peptidase-4, which is a GLP-1 inactivating enzyme, have been developed for treatment of type 2 diabetes. In addition to glucose-lowering effects, emerging data suggests that GLP-1-based therapies also showanti-inflammatory effects in chronic inflammatory diseases including type 1 and 2 diabetes, atherosclerosis, neurodegenerative disorders, nonalcoholic steatohepatitis, diabetic nephropathy, asthma, and psoriasis. This review outlines the anti-inflammatory actions of GLP-1-based therapies on diseases associated with chronic inflammation in vivo and in vitro, and their molecular mechanisms of anti-inflammatory action.

引用

页数：11

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