Delayed P2X4R expression after hypoxia-ischemia is associated with microglia in the immature rat brain

被引：47
作者：
Wixey, Julie A. [1 ]
Reinebrant, Hanna E. [1 ]
Carty, Michelle L. [1 ]
Buller, Kathryn M. [1 ]
机构：
[1] Univ Queensland, Clin Res Ctr, Herston, Qld 4029, Australia
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 212卷 / 1-2期
关键词：
Hypoxia-ischemia; Microglia; P2X(4) receptor; Minocycline; WHITE-MATTER INJURY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; INDUCED NEUROLOGICAL DYSFUNCTION; STRETCH-INDUCED INJURY; LOW-BIRTH-WEIGHT; EXTRACELLULAR ATP; CELL-DEATH; PERIVENTRICULAR LEUKOMALACIA; LESIONAL ACCUMULATION; PURINERGIC RECEPTORS;
D O I：
10.1016/j.jneuroim.2009.04.016
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In a preterm hypoxia-ischemia model in the post-natal day 3 rat, we characterized how the expression of purine ionotropic P2X(4) receptors change in the brain post-insult. After hypoxia-ischemia, P2X(4) receptor expression increased significantly and was associated with a late increase in ionised calcium binding adapter molecule-1 protein expression indicative of microglia cell activation. Minocycline, a potent inhibitor of microglia, attenuated the hypoxia-ischemia-induced increase in P2X(4) receptor expression. We postulate that P2X(4) receptor-positive microglia may represent a population of secondary injury-induced activated microglia. Future studies will determine whether this population contributes to the progression of injury in the immature brain. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：35 / 43
页数：9
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