Long-term survival of a dog with Alexander disease

被引：1

作者：

Kobatake, Yui ^{[1
]}

Nishimura, Nao ^{[1
]}

Sakai, Hiroki ^{[1
,2
,3
]}

Iwana, Syunsuke ^{[4
]}

Yamato, Osamu ^{[5
]}

Nishii, Naohito ^{[1
,2
]}

Kamishina, Hiroaki ^{[1
,2
,3
]}

机构：

[1] Gifu Univ, Fac Appl Biol Sci, Gifu 5011193, Japan

[2] Gifu Univ, United Grad Sch Vet Sci, Gifu 5011193, Japan

[3] Gifu Univ, Ctr Highly Adv Integrat Nano & Life Sci, Gifu 5011193, Japan

[4] Kohnan Anim Hosp, Konan, Aichi 4838085, Japan

[5] Kagoshima Univ, Joint Fac Vet Med, Kagoshima 8900065, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2020年 / 82卷 / 11期

关键词：

Alexander disease; astrocyte; canine; neurodegenerative disease; Rosenthal fibers; ROSENTHAL FIBER FORMATION; MYELOENCEPHALOPATHY; MUTATIONS; ENCEPHALOPATHY; ONSET;

D O I：

10.1292/jvms.20-0133

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

A 1-year- and 11-month-old spayed female toy poodle had showed progressive ataxia and paresis in the hindlimbs since 11 months old. Magnetic resonance imaging revealed high signal intensity on T2-weighted and fluid-attenuated inversion recovery images at the thoracic and lumbar spinal cord. The dog's neurological condition slowly deteriorated and flaccid tetraparesis was exhibited. At 4 years and 11 months old, the dog died of respiratory failure. On postmortem examination, eosinophilic corkscrew bundles (Rosenthal fibers) were observed mainly in the thoracic and lumbar spinal cord. Histological features were comparable to previously reported cases with Alexander disease. This is a first case report to describe the clinical course and long-term prognosis of a dog with Alexander disease.

引用

页码：1704 / 1707

页数：4

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