Defining abnormal slow EEG activity in acute ischaemic stroke: Delta/alpha ratio as an optimal QEEG index

被引:158
作者
Finnigan, Simon [1 ,2 ]
Wong, Andrew [3 ,4 ]
Read, Stephen [3 ,4 ]
机构
[1] Univ Queensland, UQ Ctr Clin Res, Herston, Qld 4029, Australia
[2] Royal Brisbane & Womens Hosp, Metro North Hosp & Hlth Serv, Ctr Allied Hlth Res, Brisbane, Qld, Australia
[3] Univ Queensland, Sch Med, Brisbane, Qld, Australia
[4] Royal Brisbane & Womens Hosp, Metro North Hosp & Hlth Serv, Acute Stroke Unit, Dept Neurol, Brisbane, Qld, Australia
基金
英国医学研究理事会;
关键词
Acute ischaemic stroke; Quantitative electroencephalography; Delta activity; Alpha activity; MILD COGNITIVE IMPAIRMENT; QUANTITATIVE EEG; FUNCTIONAL STATUS; UNIQUELY INFORM; POWER;
D O I
10.1016/j.clinph.2015.07.014
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: Quantitative electroencephalographic (QEEG) indices sensitive to abnormal slow (relative to faster) activity power seem uniquely informative for clinical management of ischaemic stroke (IS), including around acute reperfusion therapies. However these have not been compared between IS and control samples. The primary objective was to identify the QEEG slowing index and threshold value which can most accurately discriminate between IS patients and controls. Methods: The samples comprised 28 controls (mean age: 70.4; range: 56-84) and 18 patients (mean age: 69.3; range: 51-86). Seven indices were analysed: relative bandpower (delta, theta, alpha, beta), delta/alpha power ratio (DAR), (delta + theta)/(alpha + beta) ratio (DTABR) and Q(SLOWING). The accuracies of each index for classifying participants (IS or control) were analysed using receiver operating characteristic (ROC) techniques. Results: All indices differed significantly between the samples (p < .001). DAR alone exhibited optimal classifier accuracy, with a threshold of 3.7 demonstrating 100% sensitivity and 100% specificity for discriminating between radiologically-confirmed, acute IS or control. DTABR and relative delta were the next most accurate classifiers. Conclusions: DAR of 3.7 demonstrated maximal accuracy for classifying all 46 participants as acute IS or control. Significance: DAR assessment may inform clinical management of IS and perhaps other neurocritical patients. (C) 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:1452 / 1459
页数:8
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