Bone regeneration and graft material resorption in extraction sockets grafted with bioactive silica-calcium phosphate composite (SCPC) versus non-grafted sockets: clinical, radiographic, and histological findings

被引:9
作者
Adel-Khattab, Doaa [1 ]
Afifi, Nermeen S. [2 ,3 ]
Abu El Sadat, Shaimaa M. [4 ]
Aboul-Fotouh, Mona N. [5 ]
Tarek, Karim [6 ]
Horowitz, Robert A. [7 ,8 ,9 ]
机构
[1] Ain Shams Univ, Dept Oral Med Periodontol & Diag, Fac Dent, Cairo, Egypt
[2] Ain Shams Univ, Dept Oral Pathol, Fac Dent, Cairo, Egypt
[3] Misr Int Univ, Dept Oral Pathol, Fac Dent, Cairo, Egypt
[4] Ain Shams Univ, Dept Oral Radiol, Fac Dent, Cairo, Egypt
[5] Ain Shams Univ, Master Periodontol & Implantol, Fac Dent, Cairo, Egypt
[6] Ain Shams Univ, Master Oral Surg, Fac Dent, Cairo, Egypt
[7] NYU, Coll Dent, Dept Oral Surg, 2 Overhill Rd,Suite 270 Scarsdale, New York, NY 10583 USA
[8] NYU, Coll Dent, Dept Periodontol, 2 Overhill Rd,Suite 270 Scarsdale, New York, NY 10583 USA
[9] NYU, Coll Dent, Dept Implant Dent, 2 Overhill Rd,Suite 270 Scarsdale, New York, NY 10583 USA
关键词
Alveolar ridge augmentation; Cone beam computed tomography; Histological techniques; RIDGE PRESERVATION; POST-EXTRACTION; AUGMENTATION; MINERALIZATION; DISSOLUTION; SUBSTITUTE; EXPRESSION; MEMBRANE; MATRIX;
D O I
10.5051/jpis.2000040002
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Purpose: The purpose of the present study was to evaluate the effect of silica-calcium phosphate composite (SCPC) granules on bone regeneration in extraction sockets. Methods: Ten patients were selected fora split-model study. In each patient, bone healing in SCPC-grafted and control ungrafted sockets was analyzed through clinical, radiographic, histomorphometric, and immunohistochemical assessments 6 months postoperatively. Results: A radiographic assessment using cone-beam computed tomography showed minimal ridge dimension changes in SCPC-grafted sockets, with 0.39 mm and 1.79 mm decreases in height and width, respectively. Core bone biopsy samples were obtained 6 months post-extraction during implant placement and analyzed. The average percent areas occupied by mature bone, woven bone, and remnant particles in the SCPC-grafted sockets were 41.3%+/- 12%, 20.1%+/- 9.5%, and 5.3%+/- 4.4%, respectively. The percent areas of mature bone and woven bone formed in the control ungrafted sockets at the same time point were 31%+/- 14% and 24.1%+/- 9.4%, respectively. Histochemical and immunohistochemical analyses showed dense mineralized bundles of type I collagen with high osteopontin expression intensity in the grafted sockets. The newly formed bone was well vascularized, with numerous active osteoblasts, Haversian systems, and osteocytes indicating maturation. In contrast, the new bone in the control ungrafted sockets was immature, rich in type III collagen, and had a low osteocyte density. Conclusions: The resorption of SCPC granules in 6 months was coordinated with better new bone formation than was observed in untreated sockets. SCPC is a resorbable bone graft material that enhances bone formation and maturation through its stimulatory effect on bone cell function.
引用
收藏
页码:418 / 434
页数:17
相关论文
共 39 条
[1]  
Aghaloo TL, 2007, INT J ORAL MAX IMPL, V22, P49
[2]  
Al-Sabbagh Mohanad, 2013, J Int Acad Periodontol, V15, P91
[3]   Early osteoblast responses to orthopedic implants: Synergy of surface roughness and chemistry of bioactive ceramic coating [J].
Aniket ;
Reid, Robert ;
Hall, Benika ;
Marriott, Ian ;
El-Ghannam, Ahmed .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2015, 103 (06) :1961-1973
[4]  
[Anonymous], 2015, J Oral Sci Rehabil
[5]   Qualitative and quantitative expression of bovine bone mineral in experimental bone defects. Part 2: Morphometric analysis [J].
Artzi, Z ;
Givol, N ;
Rohrer, MD ;
Nemcovsky, CE ;
Prasad, HS ;
Tal, H .
JOURNAL OF PERIODONTOLOGY, 2003, 74 (08) :1153-1160
[6]   Porous bovine bone mineral in healing of human extraction sockets. part 1: Histomorphometric evaluations at 9 months [J].
Artzi, Z ;
Tal, H ;
Dayan, D .
JOURNAL OF PERIODONTOLOGY, 2000, 71 (06) :1015-1023
[7]   Tissue changes of extraction sockets in humans: a comparison of spontaneous healing vs. ridge preservation with secondary soft tissue healing [J].
Barone, Antonio ;
Ricci, Massimiliano ;
Tonelli, Paolo ;
Santini, Stefano ;
Covani, Ugo .
CLINICAL ORAL IMPLANTS RESEARCH, 2013, 24 (11) :1231-1237
[8]   Histologic Analysis of Healing After Tooth Extraction With Ridge Preservation Using Mineralized Human Bone Allograft [J].
Beck, Tina M. ;
Mealey, Brian L. .
JOURNAL OF PERIODONTOLOGY, 2010, 81 (12) :1765-1772
[9]   Clinical relevance of dimensional bone and soft tissue alterations post-extraction in esthetic sites [J].
Chappuis, Vivianne ;
Araujo, Mauricio G. ;
Buser, Daniel .
PERIODONTOLOGY 2000, 2017, 73 (01) :73-83
[10]  
Choukroun J., 2001, Implantodontie, V42, P55, DOI DOI 10.1051/MBCB/2013074