Highly Enantioselective Cu-Catalyzed Conjugate Addition-Elimination of Activated Allylic Acetates with Glycine Derivatives

被引：44
作者：
Chen, Chun-Gen [1 ]
Hou, Xue-Long [1 ]
Pu, Lin [2 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
[2] Univ Virginia, Dept Chem, Charlottesville, VA 22904 USA
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 10期
基金：
中国国家自然科学基金;
关键词：
ALPHA-AMINO-ACIDS; PHASE-TRANSFER CATALYSIS; BAYLIS-HILLMAN ACETATES; ASYMMETRIC 1,3-DIPOLAR CYCLOADDITION; QUATERNARY AMMONIUM-SALTS; CHIRAL CALCIUM COMPLEXES; AZOMETHINE YLIDES; SCHIFF-BASE; KINETIC RESOLUTION; GAMMA-BUTENOLIDES;
D O I：
10.1021/ol900439h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of a glycinate Schiff base with the activated alkyl- and aryl-substituted allylic acetates afforded 4-alkylidenylglutamic acid derivatives in high yields and high enantioselectivities by using Cu/P,N-FcPhox as the catalyst.
引用
收藏
页码：2073 / 2075
页数：3
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