Highly Enantioselective Cu-Catalyzed Conjugate Addition-Elimination of Activated Allylic Acetates with Glycine Derivatives

被引：44

作者：

Chen, Chun-Gen ^{[1
]}

Hou, Xue-Long ^{[1
]}

Pu, Lin ^{[2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

[2] Univ Virginia, Dept Chem, Charlottesville, VA 22904 USA

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 10期

基金：

中国国家自然科学基金;

关键词：

ALPHA-AMINO-ACIDS; PHASE-TRANSFER CATALYSIS; BAYLIS-HILLMAN ACETATES; ASYMMETRIC 1,3-DIPOLAR CYCLOADDITION; QUATERNARY AMMONIUM-SALTS; CHIRAL CALCIUM COMPLEXES; AZOMETHINE YLIDES; SCHIFF-BASE; KINETIC RESOLUTION; GAMMA-BUTENOLIDES;

D O I：

10.1021/ol900439h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of a glycinate Schiff base with the activated alkyl- and aryl-substituted allylic acetates afforded 4-alkylidenylglutamic acid derivatives in high yields and high enantioselectivities by using Cu/P,N-FcPhox as the catalyst.

引用

页码：2073 / 2075

页数：3

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