Membrane phospholipid synthesis and endoplasmic reticulum function

被引：342

作者：

Fagone, Paolo ^{[1
]}

Jackowski, Suzanne ^{[1
]}

机构：

[1] St Jude Childrens Hosp, Dept Infect Dis, Memphis, TN 38105 USA

来源：

JOURNAL OF LIPID RESEARCH | 2009年 / 50卷

基金：

美国国家卫生研究院;

关键词：

phospholipids; sphingolipids; plasmalogens; unfolded protein response; CTP-PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE; CDP-DIACYLGLYCEROL-SYNTHASE; UNFOLDED PROTEIN RESPONSE; GOLGI SECRETORY FUNCTION; PHOSPHATIDYLCHOLINE SYNTHESIS; MAMMALIAN-TISSUES; BIOSYNTHESIS; APPARATUS; CELLS; BIOGENESIS;

D O I：

10.1194/jlr.R800049-JLR200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review presents an overview of mammalian phospholipid synthesis and the cellular locations of the biochemical activities that produce membrane lipid molecular species. The generalized endoplasmic reticulum compartment is a central site for membrane lipid biogenesis, and examples of the emerging relationships between alterations in lipid composition, regulation of membrane lipid biogenesis, and cellular secretory function are discussed.-Fagone, P., and S. Jackowski. Membrane phospholipid synthesis and endoplasmic reticulum function. J. Lipid Res. 2009. S311-S316.

引用

页码：S311 / S316

页数：6

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