Membrane phospholipid synthesis and endoplasmic reticulum function

被引：328
作者：
Fagone, Paolo [1 ]
Jackowski, Suzanne [1 ]
机构：
[1] St Jude Childrens Hosp, Dept Infect Dis, Memphis, TN 38105 USA
来源：
JOURNAL OF LIPID RESEARCH | 2009年 / 50卷
基金：
美国国家卫生研究院;
关键词：
phospholipids; sphingolipids; plasmalogens; unfolded protein response; CTP-PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE; CDP-DIACYLGLYCEROL-SYNTHASE; UNFOLDED PROTEIN RESPONSE; GOLGI SECRETORY FUNCTION; PHOSPHATIDYLCHOLINE SYNTHESIS; MAMMALIAN-TISSUES; BIOSYNTHESIS; APPARATUS; CELLS; BIOGENESIS;
D O I：
10.1194/jlr.R800049-JLR200
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review presents an overview of mammalian phospholipid synthesis and the cellular locations of the biochemical activities that produce membrane lipid molecular species. The generalized endoplasmic reticulum compartment is a central site for membrane lipid biogenesis, and examples of the emerging relationships between alterations in lipid composition, regulation of membrane lipid biogenesis, and cellular secretory function are discussed.-Fagone, P., and S. Jackowski. Membrane phospholipid synthesis and endoplasmic reticulum function. J. Lipid Res. 2009. S311-S316.
引用
收藏
页码：S311 / S316
页数：6
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