A common clonal origin of nodal marginal zone B-cell lymphoma and plasma cell myeloma demonstrating different immunophenotypes - A case report of composite lymphoma

被引:8
|
作者
Saito, H
Oka, K
Nakamura, N
Nagayama, R
Hakozaki, H
Mori, N
机构
[1] Mito Saiseika Gen Hosp, Dept Pathol, Mito, Ibaraki 3114198, Japan
[2] Mito Saiseika Gen Hosp, Dept Hematol, Mito, Ibaraki 3114198, Japan
[3] Fukushima Med Univ, Sch Med, Dept Pathol, Fukushima, Japan
[4] Fukushima Rosai Hosp, Dept Pathol, Iwaki, Fukushima, Japan
[5] Nagoya Univ, Dept Pathol Biol Response, Grad Sch Med, Nagoya, Aichi, Japan
关键词
composite lymphoma; plasma cell myeloma; nodal marginal zone B-cell lymphoma; Southern blotting; sequence analysis of CDR3; plasma cell differentiation; a common clonal origin; different immunophenotypes;
D O I
10.1097/00019606-200406000-00003
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We demonstrated an 83-year-old male case of composite lymphoma. Before IS years, he was diagnosed with nodal marginal zone B-cell lymphoma in the cervical lymph node. Peripheral blood showed anemia and IgA (kappa)-type monoclonal gammopathy (IgA; 3.625 mg/dL). Bone marrow aspiration biopsy exhibited plasma cell myeloma, in which atypical plasma cells were positive for cytoplasmic IgA (kappa) and atypical lymphoid cells intermingled were positive for CD20. In contrast, cervical lymph node biopsy revealed nodal marginal zone B-cell lymphoma, in which lymphoma cells were positive for cytoplasmic IgG (lambda). Southern blotting analysis of the IgH gene showed same clonal rearrangement band in both lymph node and bone marrow samples and additional band in the bone marrow. Sequence analyses of the IgH gene showed an identical sequence of CDR3 in both samples. Thus, we demonstrated a common clonal origin of composite lymphoma comprising nodal marginal zone B-cell lymphoma and plasma cell myeloma. Nodal marginal zone B-cell lymphoma recurred in cervical lymph node and involved into the bone marrow. differentiating into plasma cell myeloma in which Ig isotype switched and monoclonal gammopathy developed. Sequence analysis of the IgH gene was a powerful tool for determination of clonal origin.
引用
收藏
页码:75 / 80
页数:6
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