Eclipta alba extract with potential for hair growth promoting activity

被引:91
作者
Datta, Kakali [1 ]
Singh, Anu T. [1 ]
Mukherjee, Ashok [1 ]
Bhat, Beena [1 ,2 ]
Ramesh, B. [2 ]
Burman, Anand C. [1 ]
机构
[1] Dabur Res Fdn, Mol Oncol Lab, Sahibabad 201010, Ghaziabad, India
[2] Chaudhary Charan Singh Univ, Dept Genet & Plant Breeding, Meerut, Uttar Pradesh, India
关键词
Anagen; Telogen; Hair growth promotion; Melanogenesis; Surrogate markers; Follicles; Skin thickness; INDUCTION; ANAGEN; EXPRESSION; HEDGEHOG; MELANOGENESIS; SKIN; FOLLICLES; GENES; PHASE;
D O I
10.1016/j.jep.2009.05.023
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Ethnopharmacological relevance: Eclipta alba is traditionally known to potentiate hair growth promotion. Aim of the study: The study was aimed to investigate the efficacy of methanol extract of Eclipta alba as hair growth promoter. Materials and methods: Pigmented C57/BL6 mice, preselected for their telogen phase of hair growth were used. In these species, the truncal epidermis lacks melanin-producing melanocytes and melanin production is strictly coupled to anagen phase of hair growth. The extract was applied topically to assess telogen to anagen transition. Immunohistochemical investigation was performed to analyze antigen specificity. Animals in anagen phase of hair growth were positive for FGF-7 and Shin and negative for BMP4, whereas the animals in telogen phase were positive only for BMP4 antigen. Results: The methanol extract of whole plant when tested for hair growth promoting potential, exhibited dose dependent activity in C57BL6 mice. The activity was assessed by studying the melanogenesis in resected skin, follicle count in the subcutis. skin thickness and surrogate markers in vehicle control and extract treated animals. Conclusion: These findings suggest that methanol extract of Eclipta alba may have potential as a hair growth promoter. (C) 2009 Published by Elsevier Ireland Ltd.
引用
收藏
页码:450 / 456
页数:7
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