Clinical Messages From the Treatment for Adolescents With Depression Study (TADS)

被引：38

作者：

March, John S. ^{[1
]}

Vitiello, Benedetto ^{[2
]}

机构：

[1] Duke Univ, Med Ctr, Duke Clin Res Inst, Div Neurosci Med, Durham, NC 27705 USA

[2] NIMH, Bethesda, MD 20892 USA

来源：

AMERICAN JOURNAL OF PSYCHIATRY | 2009年 / 166卷 / 10期

关键词：

COGNITIVE-BEHAVIORAL THERAPY; COST-EFFECTIVENESS; SUICIDAL IDEATION; MAJOR DEPRESSION; RESEARCH FORUM; CHILDREN; PLACEBO; SAFETY; PSYCHOTHERAPY; ALTERNATIVES;

D O I：

10.1176/appi.ajp.2009.08101606

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: The purpose of this report was to summarize the key clinical messages from the Treatment for Adolescents with Depression Study (TADS). Methods: TADS is a National Institute of Mental Health (NIMH)-funded randomized controlled trial designed to evaluate the relative effectiveness of fluoxetine, cognitive-behavioral therapy (CBT), and the combination of fluoxetine plus CBT across acute treatment, maintenance treatment, and naturalistic follow-up periods among adolescents with major depressive disorder. Results: Findings revealed that 6 to 9 months of combined fluoxetine plus CBT should be the modal treatment from a public health perspective as well as to maximize benefits and minimize harms for individual patients. Conclusion: The combination of fluoxetine and CBT appears to be superior to both CBT monotherapy and fluoxetine monotherapy as a treatment for moderate to severe major depressive disorder in adolescents.

引用

页码：1118 / 1123

页数：6

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