Obsessive-compulsive disorder patients display enhanced latent inhibition on a visual search task

被引:18
作者
Kaplan, Oren
Dar, Reuven
Rosenthal, Lirona
Hermesh, Haggai
Fux, Mendel
Lubow, R. E. [1 ]
机构
[1] Tel Aviv Univ, Dept Psychol, IL-69978 Tel Aviv, Israel
[2] Coll Management, Rishon Leziyyon, Israel
[3] Geha Mental Hlth Ctr, Petah Tiqwa, Israel
[4] Beer Sheva Mental Hlth Ctr, Beer Sheva, Israel
基金
以色列科学基金会;
关键词
obsessive-compulsive disorder (OCD); latent inhibition; visual search; attention; anxiety; schizophrenia;
D O I
10.1016/j.brat.2005.09.005
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Latent inhibition (LI) is a phenomenon that reflects the ability to ignore irrelevant stimuli. LI is attenuated in some schizophrenic patient groups and in high schizotypal normal participants. One study has found enhanced LI in patients with obsessive-compulsive disorder (OCD [Swerdlow, N. R., Hartston, H. J., & Hartman, P. L., 1999. Enhanced visual latent inhibition in obsessive-compulsive disorder. Biological Psychiatry, 45, 482-488]). The present experiment replicated this finding using a within-subject visual search LI task, with OCD patients displaying more LI than healthy controls. The contrasting LI effects in schizophrenia and OCD are discussed in terms of how these groups differentially process relevant and irrelevant stimuli, and how that outcome affects subsequent behavior. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1137 / 1145
页数:9
相关论文
共 46 条
[1]   THE DISORDER OF CONSCIOUSNESS IN SCHIZOPHRENIA [J].
ANSCOMBE, R .
SCHIZOPHRENIA BULLETIN, 1987, 13 (02) :241-260
[2]   Pathophysiology of obsessive-compulsive disorder - A necessary link between phenomenology, neuropsychology, imagery and physiology [J].
Aouizerate, B ;
Guehl, D ;
Cuny, E ;
Rougier, A ;
Bioulac, B ;
Tignol, J ;
Burbaud, P .
PROGRESS IN NEUROBIOLOGY, 2004, 72 (03) :195-221
[3]  
APA A.P. A., 2000, Diagnostic and statistical manual of mental disorders: DSM-IV, V4th
[4]   DIFFERENTIAL PERFORMANCE OF ACUTE AND CHRONIC-SCHIZOPHRENICS IN A LATENT INHIBITION TASK [J].
BARUCH, I ;
HEMSLEY, DR ;
GRAY, JA .
JOURNAL OF NERVOUS AND MENTAL DISEASE, 1988, 176 (10) :598-606
[5]   Stimulus generalization, context change, and forgetting [J].
Bouton, ME ;
Nelson, JB ;
Rosas, JM .
PSYCHOLOGICAL BULLETIN, 1999, 125 (02) :171-186
[6]   Latent inhibition deficits in high-schizotypal normals: symptom-specific or anxiety-related? [J].
Braunstein-Bercovitz, H ;
Rammsayer, T ;
Gibbons, H ;
Lubow, RE .
SCHIZOPHRENIA RESEARCH, 2002, 53 (1-2) :109-121
[7]   Selective attention in obsessive-compulsive disorder [J].
Clayton, IC ;
Richards, JC ;
Edwards, CJ .
JOURNAL OF ABNORMAL PSYCHOLOGY, 1999, 108 (01) :171-175
[8]   The relation between latent inhibition and symptom-types in young schizophrenics [J].
Cohen, E ;
Sereni, N ;
Kaplan, O ;
Weizman, A ;
Kikinzon, L ;
Weiner, I ;
Lubow, RE .
BEHAVIOURAL BRAIN RESEARCH, 2004, 149 (02) :113-122
[9]  
DAR R, 1991, INT REV PSYCHIATR, V1, P235
[10]   A study of parallel implicit and explicit information processing in patients with obsessive-compulsive disorder [J].
Deckersbach, T ;
Savage, CR ;
Curran, T ;
Bohne, A ;
Wilhelm, S ;
Baer, L ;
Jenike, MA ;
Rauch, SL .
AMERICAN JOURNAL OF PSYCHIATRY, 2002, 159 (10) :1780-1782