Sex differences in substance use, health, and social functioning among opioid users receiving methadone treatment: a multicenter cohort study

被引：65

作者：

Bawor, Monica ^{[1
,2
,3
,4
]}

Dennis, Brittany B. ^{[2
,3
,4
,5
]}

Varenbut, Michael ^{[6
]}

Daiter, Jeff ^{[6
]}

Marsh, David C. ^{[6
,8
]}

Plater, Carolyn ^{[6
]}

Worster, Andrew ^{[5
,6
,7
]}

Steiner, Meir ^{[9
,10
,11
]}

Anglin, Rebecca ^{[7
,9
]}

Pare, Guillaume ^{[3
,5
]}

Desai, Dipika ^{[3
]}

Thabane, Lehana ^{[5
,12
]}

Samaan, Zainab ^{[3
,4
,5
,9
,13
]}

机构：

[1] McMaster Univ, MiNDS Neurosci Grad Program, Hamilton, ON, Canada

[2] Univ London, London, England

[3] McMaster Univ, Populat Genom Program, Chanchlani Res Ctr, Hamilton, ON, Canada

[4] St Josephs Healthcare Hamilton, Peter Boris Ctr Addict Res, Hamilton, ON, Canada

[5] McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada

[6] CATC, Richmond Hill, ON, Canada

[7] McMaster Univ, Dept Med, Hamilton, ON, Canada

[8] Northern Ontario Sch Med, Sudbury, ON, Canada

[9] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada

[10] St Josephs Healthcare Hamilton, Womens Hlth Concerns Clin, Hamilton, ON, Canada

[11] McMaster Univ, Dept Obstet & Gynecol, Hamilton, ON, Canada

[12] Ctr Evaluat Med, Biostat Unit, Hamilton, ON, Canada

[13] St Josephs Healthcare, Mood Disorders Program, Hamilton, ON L8N 3K7, Canada

来源：

BIOLOGY OF SEX DIFFERENCES | 2015年 / 6卷

关键词：

Substance use disorders; Opioid addiction; Methadone maintenance treatment; Sex differences; Women's health; GENDER-DIFFERENCES; MAINTENANCE TREATMENT; ADDICT CAREERS; WOMEN; PAIN; MEN; ANALGESICS; MORTALITY; OUTCOMES; PROFILE;

D O I：

10.1186/s13293-015-0038-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Despite the growing numbers of men and women with opioid use disorder in Canada, sex-specific issues in treatment have not been re-examined in the current population of patients with opioid addiction. We aimed to evaluate sex differences in substance use, health, and social functioning among men and women currently receiving methadone treatment for opioid use disorder in Ontario, Canada. Methods: We recruited 503 participants with opioid dependence disorder receiving methadone maintenance treatment. We collected data on demographics, treatment characteristics, psychiatric history, addiction severity, and drug use patterns through urinalysis. We performed adjusted univariate analyses and logistic regression to identify distinct factors affecting men and women. Results: Among our sample of 54 % (n = 266) men and 46 % women (n = 226) with mean age 38.3 years, less than half of participants were employed (35.6 %) and married (31.8 %) and had completed a high school education (27.9 %). Compared to men, women had frequent physical and psychological health problems, family history of psychiatric illness, and childcare responsibilities and began using opioids through a physician prescription. Men had higher rates of employment, cigarette smoking, and cannabis use compared to women. Conclusions: Our results have revealed different patterns of substance use, health, and social functioning among men and women currently receiving methadone treatment for opioid addiction in Ontario, Canada. This information can be used to develop an integrative treatment regimen that caters to the individual needs of men and women, as well as to inform methadone treatment protocols to include specialized services (including vocational counseling, childcare and parenting assistance, medical assistance, relationship or domestic violence counseling, etc.) and increase their availability and accessibility on a larger scale.

引用

页数：11

共 53 条

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