The miRNA-192/194 cluster regulates the Period gene family and the circadian clock

被引：112

作者：

Nagel, Remco ^{[1
]}

Clijsters, Linda ^{[1
]}

Agami, Reuven ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands

来源：

FEBS JOURNAL | 2009年 / 276卷 / 19期

关键词：

circadian clock; miRNA-192; miRNA-194; Period gene family; TRANSCRIPTION; EXPRESSION; MICRORNAS; PROTEIN; CYCLE; MAMMALS; CANCER; ARRAY;

D O I：

10.1111/j.1742-4658.2009.07229.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several biological functions in mammals are regulated in a circadian fashion. The molecular mechanisms orchestrating these circadian rhythms have been unravelled. The biological clock, with its core transcriptional unit Bmal1/CLOCK, is composed of several self-sustaining feedback loops. In this study, we describe another mechanism impinging on the core components of the circadian clock. Using a forward genetic screen, we identified the miR-192/194 cluster as a potent inhibitor of the entire Period gene family. In accordance, the exogenous expression of miR-192/194 leads to an altered circadian rhythm. Thus, our results have uncovered a new mechanism for the control of the circadian clock at the post-transcriptional level.

引用

页码：5447 / 5455

页数：9

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