Fruitful decade of fungal metabolites as anti-diabetic agents from 2010 to 2019: emphasis on α-glucosidase inhibitors

被引：18
作者：
Hussain, Hidayat [1 ]
Nazir, Mamona [2 ]
Saleem, Muhammad [3 ]
Al-Harrasi, Ahmed [4 ]
Elizbit [5 ]
Green, Ivan R. [6 ]
机构：
[1] Leibniz Inst Plant Biochem, Dept Bioorgan Chem, Weinberg 3, D-06120 Halle, Germany
[2] Govt Sadiq Coll Women Univ Bahawalpur, Dept Chem, Bahawalpur 63100, Pakistan
[3] Islamia Univ Bahawalpur, Dept Chem, Baghdad Campus, Bahawalpur 63100, Pakistan
[4] Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa 616, Oman
[5] Natl Univ Sci & Technol NUST, Dept Mat Engn, H12, Islamabad, Pakistan
[6] Univ Stellenbosch, Dept Chem & Polymer Sci, Private Bag X1, ZA-7600 Stellenbosch, South Africa
来源：
PHYTOCHEMISTRY REVIEWS | 2021年 / 20卷 / 01期
关键词：
Fungi; Secondary metabolites; α -Glucosidase; Anti-diabetic; MANGROVE ENDOPHYTIC FUNGUS; CHLORINATED DIPHENYL ETHERS; RESORCYLIC ACID LACTONES; P-TERPHENYL DERIVATIVES; SPONGE-DERIVED FUNGUS; PENICILLIUM-PURPUROGENUM; SECONDARY METABOLITE; QUINOLONE COMPOUNDS; QUINOLACTACIN-B; ACYL-COA;
D O I：
10.1007/s11101-020-09733-1
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
In recent years the prevalence of diabetes has increased globally and by 2040 the number of diabetic people has been estimated to increase to 642 million. Various classes of drugs are available to treat Type ll diabetes. However, these drugs are associated with certain side effects. alpha-Glucosidase is an intriquing target enzyme to treat Type II diabetes, and alpha-glucosidase inhibitors are considered as first-line drugs for Type ll patients. Fungi, in general, produce natural products with some amazing chemical diversity and many fungal metabolites have illustrated a wide range of biological and pharmacological effects. In this review the focus is on describing the alpha-glucosidase effects and their potential as anti-diabetic agents of various metabolites isolated from fungi.
引用
收藏
页码：145 / 179
页数：35
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