Online registry for nationwide database of Helicobacter pylori eradication in Korea: Correlation of antibiotic use density with eradication success

被引：20

作者：

Kim, Beom Jin ^{[1
]}

Yang, Chang-Hun ^{[2
]}

Song, Hyun Joo ^{[3
]}

Jeon, Seong Woo ^{[4
]}

Kim, Gwang Ha ^{[5
]}

Kim, Hyun-Soo ^{[6
]}

Kim, Tae Ho ^{[7
]}

Shim, Ki-Nam ^{[8
]}

Chung, Il-Kwun ^{[9
]}

Park, Moo In ^{[10
]}

Choi, Il Ju ^{[11
]}

Kim, Ji Hyun ^{[12
]}

Kim, Byung-Wook ^{[13
]}

Baik, Gwang Ho ^{[14
]}

Han, Sok Won ^{[7
]}

Seo, Hyang Eun ^{[15
]}

Jung, Woon Tae ^{[16
]}

Hwan Oh, Jung ^{[17
]}

Kim, Sang Gyun ^{[18
,19
]}

Lee, Jun Haeng ^{[20
]}

Park, Sue K. ^{[21
,22
,23
]}

Park, Byung-Joo ^{[21
]}

Yang, Bo Ram ^{[22
]}

Lee, Joongyub ^{[24
]}

Kim, Jae G. ^{[1
]}

机构：

[1] Chung Ang Univ, Dept Internal Med, Coll Med, Seoul, South Korea

[2] Dongguk Univ, Coll Med, Gyeongju Hosp, Dept Internal Med, Gyeongju, South Korea

[3] Jeju Natl Univ, Sch Med, Dept Internal Med, Jeju, South Korea

[4] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea

[5] Pusan Natl Univ, Sch Med, Dept Internal Med, Busan, South Korea

[6] Chonnam Natl Univ, Med Sch, Dept Internal Med, Gwangju, South Korea

[7] Catholic Univ Korea, Bucheon St Marys Hosp, Dept Gastroenterol, Coll Med, Bucheon, South Korea

[8] Ewha Womans Univ, Sch Med, Dept Internal Med, Seoul, South Korea

[9] Soon Chun Hyang Univ, Cheonan Hosp, Dept Internal Med, Coll Med, Cheonan, South Korea

[10] Kosin Univ, Coll Med, Dept Internal Med, Gospel Hosp, Busan, South Korea

[11] Natl Canc Ctr, Ctr Gastr Canc, Gyeonggi, South Korea

[12] Inje Univ, Pusan Paik Hosp, Dept Internal Med, Coll Med, Busan, South Korea

[13] Catholic Univ Korea, Coll Med, Dept Internal Med, Incheon, South Korea

[14] Hallym Univ, Dept Internal Med, Coll Med, Seoul, South Korea

[15] Daegu Fatima Hosp, Dept Internal Med, Daegu, South Korea

[16] Gyeongsang Natl Univ, Dept Internal Med, Sch Med, Jinju, South Korea

[17] Catholic Univ Korea, Coll Med, Dept Internal Med, St Pauls Hosp, Seoul, South Korea

[18] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[19] Seoul Natl Univ, Coll Med, Liver Res Inst, Seoul, South Korea

[20] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Med, Seoul, South Korea

[21] Seoul Natl Univ, Dept Prevent Med, Coll Med, Seoul, South Korea

[22] Seoul Natl Univ, Dept Biomed Sci, Grad Sch, Seoul, South Korea

[23] Seoul Natl Univ, Res Inst, Seoul, South Korea

[24] Inha Univ, Sch Med, Inha Univ Hosp, Dept Prevent & Management, Incheon, South Korea

来源：

HELICOBACTER | 2019年 / 24卷 / 05期

关键词：

antibiotic use; eradication success; first-line therapy; Helicobacter pylori; online registry; RESISTANCE; THERAPY; CLARITHROMYCIN; METRONIDAZOLE; TRIPLE; RATES;

D O I：

10.1111/hel.12646

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background The Helicobacter pylori eradication rate has decreased with increasing antibiotic resistance. We conducted a prospective, nationwide, multicenter registry study to monitor the real status of H. pylori eradication therapy and to investigate the association between eradication success and antibiotic use density in Korea. Materials and Methods We enrolled 9318 patients undergoing H. pylori eradication therapy from 37 hospitals through "on-line database registry" from October 2010 to July 2015. Demographic data, detection methods, treatment indications, regimens, durations, compliance, adverse events, and eradication results were collected. The use of all commercially available eradication antibiotics was analyzed through the Korean National Health Insurance data of the Health Insurance Review and Assessment Service. The defined daily dose of antibiotics was used to standardize drug use comparisons. Results Finally, 6738 patients were analyzed. The overall eradication rate of first-line therapy was 71.8%. The eradication success rates were 71.7%, 86.9%, and 74.0% for standard triple therapy for 7 days, quadruple therapy, and concomitant therapy, respectively. The eradication success rate in naive patients was higher than that in those who previously underwent H. pylori eradication. Eradication success was significantly associated with younger age, female sex, and high compliance. Regional differences in eradication rates were observed. The yearly use density of clarithromycin increased statistically in seven regions across the country from 2010 to 2015. The yearly use density of amoxicillin in the Gyeongsang and Chungcheong areas was significantly increased (P < .01), whereas that of other macrolides was significantly lower in the Gyeonggi area than in other areas (P = .01). The overall use of eradication antibiotics has increased while the eradication rate steadily decreased for 5 years. However, there was no significant correlation between antibiotic use density and eradication. Conclusion There was no relationship between the eradication rate and antibiotic use density in Korea.

引用

页数：12

共 22 条

[1] Antibiotic Resistance in Helicobacter pylori Strains and its Effect on H-pylori Eradication Rates in a Single Center in Korea [J].