[1] Univ Messina, Sch Med, Dept Clin & Expt Med & Pharmacol, I-98100 Messina, Italy
[2] IRCCS Ctr Neurol Bonino Pulejo, Messina, Italy
[3] St Bartholomews & Royal London Sch Med & Dent, Ctr Translat Med & Therapeut, William Harvey Res Inst, London, England