Axonal damage in multiple sclerosis: a complex issue in a complex disease

被引：42

作者：

Grigoriadis, N

Ben-Hur, T

Karussis, D

Milonas, I

机构：

[1] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Dept Neurol, Thessaloniki 54636, Greece

[2] Hebrew Univ Jerusalem, Hadassah Hosp, Agenes Ginges Ctr Human Neurogenet, Dept Neurol, Jerusalem, Israel

来源：

CLINICAL NEUROLOGY AND NEUROSURGERY | 2004年 / 106卷 / 03期

关键词：

multiple sclerosis; axonal damage; demyelination; inflammation; myelin; neuroprotection;

D O I：

10.1016/j.clineuro.2004.02.017

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Multiple sclerosis is no longer considered to simply be an autoimmune demyelinating disease. Axonal destruction is another central pathological feature and a contributor to the accumulating disability of disease progression. The mechanism underlying axonal pathology has not been fully clarified but does not appear to be a simple one. The relationship between axonal damage and other components of the pathological features such as demyelination, inflammation and remyelination are under intense investigation. Experimental data suggest that therapeutic interventions such as the induction of rapid remyelination may lead to the protection of axons. In addition to immunomodulation, future strategies for neuroprotection may be of great importance. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：211 / 217

页数：7

共 92 条

[91] Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial [J].