Human T Cell Leukemia Virus Type 1: Persistence and Pathogenesis

被引：98

作者：

Bangham, Charles R. M. ^{[1
]}

机构：

[1] Imperial Coll, Fac Med, Div Infect Dis, London W2 1PG, England

来源：

ANNUAL REVIEW OF IMMUNOLOGY, VOL 36 | 2018年 / 36卷

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

HTLV-1; retrovirus; latency; ATL; HAM/TSP; MYELOPATHY/TROPICAL SPASTIC PARAPARESIS; RESTRICTION FACTOR SAMHD1; I PROVIRAL LOAD; HTLV-I; INTERFERON-GAMMA; DENDRITIC CELLS; CLONAL EXPANSION; IMMUNE-RESPONSE; NEUROLOGICAL MANIFESTATIONS; MOLECULAR-MECHANISMS;

D O I：

10.1146/annurev-immunol-042617-053222

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human T cell leukemia virus type 1 (HTLV-1), also known as human T lymphotropic virus type 1, was the first exogenous human retrovirus discovered. Unlike the distantly related lentivirus HIV-1, HTLV-1 causes disease in only 5-10% of infected people, depending on their ethnic origin. But whereas HIV-1 infection and the consequent diseases can be efficiently contained in most cases by antiretroviral drug treatment, there is no satisfactory treatment for the malignant or inflammatory diseases caused by HTLV-1. The purpose of the present article is to review recent advances in the understanding of the mechanisms by which the virus persists in vivo and causes disabling or fatal diseases.

引用

页码：43 / 71

页数：29

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