In search of human oligodendroglia for myelin repair

被引：29

作者：

Buchet, Delphine ^{[2
]}

Baron-Van Evercooren, Anne ^{[1
,2
,3
]}

机构：

[1] INSERM, Lab Affect Myeline & Canaux Ion Musculaires, U975, UMR 546, F-75013 Paris, France

[2] Univ Paris 06, UMR S975, F-75013 Paris, France

[3] Grp Hosp Pitie Salpetriere, AP HP, F-75013 Paris, France

来源：

NEUROSCIENCE LETTERS | 2009年 / 456卷 / 03期

关键词：

Neural progenitor cells; Human oligodendrocytes; Cell therapy; Intracerebral grafting; Myelin repair; EMBRYONIC STEM-CELLS; CENTRAL-NERVOUS-SYSTEM; NEURAL PRECURSOR CELLS; HUMAN FETAL TELENCEPHALON; IN-VITRO DIFFERENTIATION; PDGF ALPHA-RECEPTOR; DORSAL SPINAL-CORD; NEONATAL-RAT-BRAIN; PROGENITOR CELLS; TRANSCRIPTION FACTORS;

D O I：

10.1016/j.neulet.2008.09.086

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cell therapy appears as an exciting strategy for myelin repair in pathologies where oligodendrocytes are deficient or impaired, such as leucodystrophies and multiple sclerosis. Many studies indicate that several types of rodent cells, including neural stem and progenitor cells, play a beneficial role after grafting and induce functional recovery in animal models of myelin disorders. However, the difficulties to commit human neural stem cells towards the oligodendroglial lineage have long hampered human cell-based therapy for these diseases. In this review, we present recent advances in the field and discuss the various strategies that helped overcome the challenge of human oligodendroglial differentiation. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：112 / 119

页数：8

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