Intra- and interreader reproducibility of magnetic resonance imaging for quantifying the lipid-rich necrotic core is improved with gadolinium contrast enhancement

被引:80
作者
Takaya, Norihide
Cai, Jianming
Ferguson, Marina S.
Yarnykh, Vasily L.
Chu, Baocheng
Saam, Tobias
Polissar, Nayak L.
Sherwood, Jane
Cury, Ricardo C.
Anders, Robert J.
Broschat, Kay O.
Hinton, Denise
Furie, Karen L.
Hatsukami, Thomas S.
Yuan, Chun
机构
[1] Univ Washington, Dept Radiol, Seattle, WA 98195 USA
[2] Juntendo Univ, Sch Med, Dept Cardiol, Tokyo 113, Japan
[3] Mt Whisper Light Stat Consulting, Seattle, WA USA
[4] Massachusetts Gen Hosp, Dept Cardiol, Boston, MA 02114 USA
[5] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA
[6] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA
[7] Pfizer Pharmaceut Facil, Skokie, IL USA
[8] VA Puget Sound Hlth Care Syst, Dept Surg, Seattle, WA USA
[9] Univ Washington, Seattle, WA 98195 USA
关键词
necrotic core; MRI; contrast enhancement; reproducibility; carotid artery; atherosclerosis;
D O I
10.1002/jmri.20599
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To test the hypothesis that intra- and interreader reproducibility for measuring the lipid-rich necrotic core (LR-NC) size is significantly improved with gadolinium (Gd) contrast-enhanced magnetic resonance imaging (CEMRI) compared to non-CEMRI. Materials and Methods: Thirty-seven individuals with > 50% carotid artery stenosis underwent carotid MRI at 1.5T (pre- and postcontrast T1-weighted (T1W), T2-weighted (T2W), proton density-weighted (PDW), and three-dimensional time-of-flight (TOF) sequences). Two independent readers measured the mean area of the LR-NC from the precontrast images only, followed by a second measurement using the additional postcontrast images. One reader repeated the measurements after an interval of five months. Intra- and interreader reproducibility was analyzed by means of the intraclass correlation coefficient (ICC), coefficient of variation (CV), and standard deviation (SD). Results: The CV decreased from 33.7% to 8.8% for intrareader measurements of the LR-NC, and from 33.5% to 17.6% for interreader measurements. The SD was significantly smaller with CEMRI than with non-CEMRI (P = 0.003 and P = 0.006, respectively). The ICC increased from 0.94 to 0.99 and from 0.85 to 0.93 for the intra- and interreader measurements, respectively. Conclusion: Reader reproducibility for in vivo MRI quantification of LR-NC size is significantly improved by the addition of Gd contrast in individuals with > 50% carotid stenosis.
引用
收藏
页码:203 / 210
页数:8
相关论文
共 40 条
[1]   Tracking regression and progression of atherosclerosis in human carotid arteries using high-resolution magnetic resonance imaging [J].
Adams, GJ ;
Greene, J ;
Vick, GW ;
Harrist, D ;
Kimball, KT ;
Karmonik, C ;
Ballantyne, CM ;
Insull, W ;
Morrisett, JD .
MAGNETIC RESONANCE IMAGING, 2004, 22 (09) :1249-1258
[2]   The vulnerable atherosclerotic plaque - Pathogenesis and therapeutic approach [J].
Aikawa, M ;
Libby, P .
CARDIOVASCULAR PATHOLOGY, 2004, 13 (03) :125-138
[3]   INTRACLASS CORRELATION COEFFICIENT AS A MEASURE OF RELIABILITY [J].
BARTKO, JJ .
PSYCHOLOGICAL REPORTS, 1966, 19 (01) :3-&
[4]   STATISTICS NOTES .1. CORRELATION, REGRESSION, AND REPEATED DATA [J].
BLAND, JM ;
ALTMAN, DG .
BRITISH MEDICAL JOURNAL, 1994, 308 (6933) :896-896
[5]   In vivo quantitative measurement of intact fibrous cap and lipid-rich necrotic core size in atherosclerotic carotid plaque - Comparison of high-resolution, contrast-enhanced magnetic resonance imaging and histology [J].
Cai, JM ;
Hatsukami, TS ;
Ferguson, MS ;
Kerwin, WS ;
Saam, T ;
Chu, BC ;
Takaya, N ;
Polissar, NL ;
Yuan, C .
CIRCULATION, 2005, 112 (22) :3437-3444
[6]  
Collins R, 2002, LANCET, V360, P7, DOI 10.1016/S0140-6736(02)09327-3
[7]   Lipid lowering by simvastatin induces regression of human atherosclerotic lesions - Two years' follow-up by high-resolution noninvasive magnetic resonance imaging [J].
Corti, R ;
Fuster, V ;
Fayad, ZA ;
Worthley, SG ;
Helft, G ;
Smith, D ;
Weinberger, J ;
Wentzel, J ;
Mizsei, G ;
Mercuri, M ;
Badimon, JJ .
CIRCULATION, 2002, 106 (23) :2884-2887
[8]  
FALK E, 1992, CIRCULATION, V86, P30
[9]   CHARACTERIZATION OF THE RELATIVE THROMBOGENICITY OF ATHEROSCLEROTIC PLAQUE COMPONENTS - IMPLICATIONS FOR CONSEQUENCES OF PLAQUE RUPTURE [J].
FERNANDEZORTIZ, A ;
BADIMON, JJ ;
FALK, E ;
FUSTER, V ;
MEYER, B ;
MAILHAC, A ;
WENG, D ;
SHAH, PK ;
BADIMON, L .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1994, 23 (07) :1562-1569
[10]   MECHANISMS OF DISEASE - THE PATHOGENESIS OF CORONARY-ARTERY DISEASE AND THE ACUTE CORONARY SYNDROMES .1. [J].
FUSTER, V ;
BADIMON, L ;
BADIMON, JJ ;
CHESEBRO, JH .
NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (04) :242-250