Tetraspanin-enriched microdomains (TEMs) are specialized membrane platforms driven by protein protein interactions that integrate membrane receptors and adhesion molecules. Tetraspanins participate in antigen recognition and presentation by antigen-presenting cells (APCs) through the organization of pattern-recognition receptors (PRRs) and their downstream induced signaling, as well as the regulation of MHC-II-peptide trafficking. T lymphocyte activation is triggered upon specific recognition of antigens present on the APC surface during immunological synapse (IS) formation. This dynamic process is characterized by a defined spatial organization involving the compartmentalization of receptors and adhesion molecules in specialized membrane domains that are connected to the underlying cytoskeleton and signaling molecules. Tetraspanins contribute to the spatial organization and maturation of the IS by controlling receptor clustering and local accumulation of adhesion receptors and integrins, their downstream signaling, and linkage to the actin cytoskeleton. This review offers a perspective on the important role of TEMs in the regulation of antigen recognition and presentation and in the dynamics of IS architectural organization.
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Cedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Cedars Sinai Med Ctr, Regenerat Med Inst, Los Angeles, CA 90048 USA
Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Goodridge, Helen S.
Reyes, Christopher N.
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Cedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Reyes, Christopher N.
Becker, Courtney A.
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Cedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Becker, Courtney A.
Katsumoto, Tamiko R.
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Univ Calif San Francisco, Dept Med, Rosalind Russell Med Res Ctr Arthrit, San Francisco, CA 94143 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Katsumoto, Tamiko R.
Ma, Jun
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Cedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Ma, Jun
Wolf, Andrea J.
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Cedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Wolf, Andrea J.
Bose, Nandita
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Biothera, Eagan, MN 55121 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Bose, Nandita
Chan, Anissa S. H.
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Biothera, Eagan, MN 55121 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Chan, Anissa S. H.
Magee, Andrew S.
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Biothera, Eagan, MN 55121 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Magee, Andrew S.
Danielson, Michael E.
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Biothera, Eagan, MN 55121 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Danielson, Michael E.
Weiss, Arthur
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Univ Calif San Francisco, Dept Med, Rosalind Russell Med Res Ctr Arthrit, San Francisco, CA 94143 USA
Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Weiss, Arthur
Vasilakos, John P.
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Biothera, Eagan, MN 55121 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Vasilakos, John P.
Underhill, David M.
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Cedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
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Washington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USAWashington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Grakoui, Arash
Bromley, Shannon K.
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Washington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USAWashington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Bromley, Shannon K.
Sumen, Cenk
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Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USAWashington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Sumen, Cenk
Davis, Mark M.
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Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USAWashington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Davis, Mark M.
Shaw, Andrey S.
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Washington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USAWashington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Shaw, Andrey S.
Allen, Paul M.
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Washington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USAWashington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Allen, Paul M.
Dustin, Michael L.
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Washington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USAWashington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
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Cedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Cedars Sinai Med Ctr, Regenerat Med Inst, Los Angeles, CA 90048 USA
Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Goodridge, Helen S.
Reyes, Christopher N.
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Cedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Reyes, Christopher N.
Becker, Courtney A.
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Cedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Becker, Courtney A.
Katsumoto, Tamiko R.
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Univ Calif San Francisco, Dept Med, Rosalind Russell Med Res Ctr Arthrit, San Francisco, CA 94143 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Katsumoto, Tamiko R.
Ma, Jun
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Cedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Ma, Jun
Wolf, Andrea J.
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Cedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Wolf, Andrea J.
Bose, Nandita
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Biothera, Eagan, MN 55121 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Bose, Nandita
Chan, Anissa S. H.
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Biothera, Eagan, MN 55121 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Chan, Anissa S. H.
Magee, Andrew S.
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Biothera, Eagan, MN 55121 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Magee, Andrew S.
Danielson, Michael E.
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Biothera, Eagan, MN 55121 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Danielson, Michael E.
Weiss, Arthur
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Univ Calif San Francisco, Dept Med, Rosalind Russell Med Res Ctr Arthrit, San Francisco, CA 94143 USA
Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Weiss, Arthur
Vasilakos, John P.
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Biothera, Eagan, MN 55121 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Vasilakos, John P.
Underhill, David M.
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Cedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USACedars Sinai Med Ctr, IBD & Immunobiol Res Inst, Los Angeles, CA 90048 USA
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Washington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USAWashington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Grakoui, Arash
Bromley, Shannon K.
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机构:
Washington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USAWashington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Bromley, Shannon K.
Sumen, Cenk
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机构:
Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USAWashington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Sumen, Cenk
Davis, Mark M.
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Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USAWashington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Davis, Mark M.
Shaw, Andrey S.
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Washington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USAWashington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Shaw, Andrey S.
Allen, Paul M.
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Washington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USAWashington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Allen, Paul M.
Dustin, Michael L.
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Washington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USAWashington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA