Intrahippocampal GMP administration improves inhibitory avoidance performance through GABAergic and glutamatergic mechanisms in rats

被引：20

作者：

Rubin, MA ^{[1
]}

Jurach, A ^{[1
]}

Zanolla, GR ^{[1
]}

Boemo, RL ^{[1
]}

Souza, DO ^{[1
]}

deMello, CF ^{[1
]}

机构：

[1] UNIV FED RIO GRANDE SUL,INST CIENCIAS BASICAS SAUDE,DEPT BIOQUIM,BR-90050170 PORTO ALEGRE,RS,BRAZIL

来源：

NEUROREPORT | 1997年 / 8卷 / 17期

关键词：

baclofen; GABAergic receptors; GMP; learning; memory; MK-801; muscimol;

D O I：

10.1097/00001756-199712010-00011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

GUANIDINO compounds play specific physiological and pathological roles in the central nervous system. We investigated the effect of an intrahippocampal infusion of GMP (a guanidino compound) administered immediately post-training on the inhibitory avoidance learning paradigm in rats. Bilateral intrahippocampal microinjection of GMP (0-30 nmol) caused a dose-dependent increase in test step-down latencies which was completely reversed by intrahippocampal co-administration of muscimol or baclofen (GABA agonists) or preadministration (15 min pre-training, i.p.) of MK-801 (an NMDA antagonist). These results provide evidence for a participation of GABA and NMDA receptors in the GMP-induced increase in the test step-down latencies.

引用

页码：3713 / 3716

页数：4

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